One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

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One Niche to Rule Both Maintenance and Loss of Stemness in HSCs Motonari Kondo  Immunity  Volume 45, Issue 6, Pages 1177-1179 (December 2016) DOI: 10.1016/j.immuni.2016.12.003 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 BM Cells Produce IL-7 Mesenchymal stem/progenitor cells, CAR cells, epithelial cells, all of which are HSC niche-forming cells, produce IL-7. HSCs, MPPs, and CLPs are located in close proximity to IL-7+ BM cells in a CXCL12-CXCR4-dependent manner. ProB cells expand in response to IL-7 produced by various IL-7+ BM cells. Immunity 2016 45, 1177-1179DOI: (10.1016/j.immuni.2016.12.003) Copyright © 2016 Elsevier Inc. Terms and Conditions

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