by Nelson Leung, Samih H. Nasr, and Sanjeev Sethi

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This lecture was conducted during the Nephrology Unit Grand Ground by a Sub- intern under Nephrology Division, Department of Medicine in King Saud University.

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by Nelson Leung, Samih H. Nasr, and Sanjeev Sethi How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing by Nelson Leung, Samih H. Nasr, and Sanjeev Sethi Blood Volume 120(16):3206-3213 October 18, 2012 ©2012 by American Society of Hematology

Laser microdissection. Laser microdissection. Congo red positive (A) glomeruli and vessels marked for microdissection from case 1 (AL with kappa light chain) and (B) glomeruli marked for microdissection from case 2 (ALECT2). Nelson Leung et al. Blood 2012;120:3206-3213 ©2012 by American Society of Hematology

Representative mass spectrometry data. Representative mass spectrometry data. (A) AL κ light chain amyloidosis showing the top 15 spectra. Mass spectrometry shows large spectra for serum amyloid P-component, apolipoprotein E, and immunoglobulin κ V-I region and κ-constant region. (B) LECT-2 amyloidosis showing large spectra for serum amyloid P-component, apolipoprotein E, and leukocyte cell derived chemotaxin-2. The probability number (> 95% is highlighted by green, 80%-94% by yellow) indicates essentially the percent homology between peptides detected in the specimens and the published amino acid sequences of their corresponding proteins. Nelson Leung et al. Blood 2012;120:3206-3213 ©2012 by American Society of Hematology

Algorithm for diagnosis and typing of renal amyloidosis used at the Mayo Clinic. Algorithm for diagnosis and typing of renal amyloidosis used at the Mayo Clinic. Diagnosis and typing in renal amyloidosis. Nelson Leung et al. Blood 2012;120:3206-3213 ©2012 by American Society of Hematology