Unraveling the genetic predisposition of ribavirin-induced anaemia

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Unraveling the genetic predisposition of ribavirin-induced anaemia Tarik Asselah, Eric Pasmant, Saïd Lyoumi Journal of Hepatology Volume 53, Issue 5, Pages 971-973 (November 2010) DOI: 10.1016/j.jhep.2010.06.007 Copyright © 2010 Terms and Conditions

Fig. 1 ITPA deficiency protects against clinically significant RBV-induced decline in Hb concentration. Adapted from Felay et al. [10]. Percentages of clinically significant anaemia at week 4 (defined as either a decline in Hb of >3g/dl and/or Hb levels <10g/dl) are shown according to rs1127354 and rs7270101 combined genotypes. Rs1127354 and rs7270101 minor variants confer reduced ITPA and induce protection against clinically significant haemolytic anaemia in hepatitis C-infected patients receiving RBV. Journal of Hepatology 2010 53, 971-973DOI: (10.1016/j.jhep.2010.06.007) Copyright © 2010 Terms and Conditions