Figure 1 Suggested biopsy-avoiding diagnostic pathway for coeliac disease Figure 1 | Suggested biopsy-avoiding diagnostic pathway for coeliac disease. Non-biopsy diagnosis of coeliac disease based on the European Society for the Study of Paediatric Gastroenterology, Hepatology and Nutrition criteria in a symptomatic child with strongly positive tissue transglutaminase 2 antibody (anti-TG2) values, >10 times the upper limit of normal (ULN), a positive endomysial IgA antibody (EMA) on another blood sample and the presence of the appropriate HLA type. On the right is the process for an asymptomatic or at-risk child. A positive anti-TG2 result should lead to biopsies and histological analysis for diagnosis. Reilly, N. R. et al. (2017) Coeliac disease: to biopsy or not? Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.121