Fig. 1. The cell-intrinsic fibroblast circadian proteome contains numerous cytoskeletal regulators. The cell-intrinsic fibroblast circadian proteome contains.

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Fig. 1. The cell-intrinsic fibroblast circadian proteome contains numerous cytoskeletal regulators. The cell-intrinsic fibroblast circadian proteome contains numerous cytoskeletal regulators. (A) Protein annotation clusters generated by DAVID containing terms enriched (P < 0.10) with rhythmic protein abundances identified by RAIN (Rhythmicity Analysis Incorporating Nonparametric methods) (P < 0.01) from the analysis of primary lung fibroblasts from PER2::LUC mice. (B) The 10 largest gene ontology (GO) (cellular compartment) terms within the rhythmic data set by protein number. (C) Mean abundance [light/heavy (L/H) ratio] of rhythmic proteins from the “actin cytoskeleton” cluster determined by three SILAC experiments with three parallel PER2::LUC measurements indicating the circadian phase (heat map). Nathaniel P. Hoyle et al., Sci Transl Med 2017;9:eaal2774 Published by AAAS