Šta sve biljke i bakterije mogu učiniti za vaš gastrointestinalni trakt? dr Jasna Jović.

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Presentation transcript:

Šta sve biljke i bakterije mogu učiniti za vaš gastrointestinalni trakt? dr Jasna Jović

HELICOBACTER PYLORI (HP)

Worldwide prevalence of Helicobacter pylori infection. Worldwide prevalence of Helicobacter pylori infection. The map shows the prevalence of H. pylori infection in different parts of the world. Note, the particularly high prevalence in sub-Saharan Africa, Latin America and the Middle East. Australasia, Switzerland, and more generally North America and Western Europe have the lowest incidence of H. pylori infection. Data derived from Asfeldt et al., 2008; Ben Mansour et al., 2016; Laszewicz et al., 2014; Luzza et al., 2014; McDonald et al., 2015; Peleteiro et al., 2014; Saltanova, 2001; Sanchez Ceballos et al., 2007; van Blankenstein et al., 2013. Michael D. Burkitt et al. Dis. Model. Mech. 2017;10:89-104 © 2017. Published by The Company of Biologists Ltd

 Rate of Stomach Cancer, Worldwide

HELICOBACTER PYLORI Dis. Model. Mech. 2017;10:89-104

Stopa eradikacije opada zbog: Rezistencije HP HELICOBACTER PYLORI 104–107 HP CFU na 1 gr mukusa Stopa eradikacije opada zbog: Rezistencije HP Neželjeni efekti terapije Nekomplijantnosti bolesnika Maastricht IV Bolesnici sa dispepsijom Testirati i Lečiti (oko 15 % ima poboljšanje tegoba)* Bolesnici HP+ bez tegoba Koji bolesnici sa HP+ će razviti Ca želuca Da li eradicirati HP kod GERB Nivo kolonizacije HP proporcionalan nastanku simprtoma i bolesti *Am J Gastroenterol 2007, 102:1808-25

Slična poodnošljivost značajno manje promene ukusa Eradikacija Grupa A 74,3% Grupa B 65,7% Ther Adv Gastroenterol,2014, 7:4–13

Ther Adv Gastroenterol,2014, 7:4–13

Lactobacillus reuteri strain DSMZ17648 Pylopass 13C UBT δ ≥ 12‰ Lactobacillus reuteri strain DSMZ17648 Pylopass 5x109 ćelija po tableti 2x2 posle jela Jednostruko slepa ukrštena studija 14 dana placebo 14 dana Pylopass p=0,011 Nutrients 2013, 5, 3062-3073

Nutrients 2013, 5, 3062-3073

Koren sladića (Glycyrrhiza glabra) Dejstva: Povećava produkciju mukusa Inhibira sintezu leukotrijena i prostaglandina Antioksidantno Inhibira 11-β hydroxyl steroid dehydrogenase Smanjuje epigastrični bol Pomaže zaceljenje ulkusa Ima antibakterijska i antivirusna svojsva 60 bolesnika (UBD) +BUT test 30 bolesnika grupa A Metronidazole, amoxicillin, omeprazole D-Reglis (sladić) 380 mg 2x1 30 bolesnika Grupa B bismut subsalicilat 262 mg 2x1 Pharmacognosy Res 201 6: 341–344

LR grupa - 83.3% Kontrola - 62.5% (p = 0.018) HPSA negative LR grupa - 83.3% Kontrola - 62.5% (p = 0.018)  The Brazilian Journal of Infectious Diseases, 2016 20: 534-538

17 mg glicirizinske kiseline

NAMENJENO pacijentima sa dispepsijom gastritisom prisustvo HP zdravima DEJSTVA Smanjenje HP Antiinflamacijski Smanjenje upale Neutralizacija histamina Manja sinteza homocisteina Podići imunitet Povoljno dejstvo na crevnu floru UZIMANJE jedna kesica posle najobilnijeg obroka u 100-200 ml razmutiti i popiti. Terpija traje 14 dana i može se ponoviti koliko je puta potrebno OPREZ kod hipertoničara dijabetičara kradijalnih problema trudnica

Ako Vaš želudac izgleda kao lice ove devojke pre vreme je za Gastrolact Pre Posle