FGF23 or PTH: which comes first in CKD ?

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FGF23 or PTH: which comes first in CKD ? Tamara Isakova, Myles S. Wolf Kidney International Volume 78, Issue 10, Pages 947-949 (November 2010) DOI: 10.1038/ki.2010.281 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Pathogenesis of disordered mineral metabolism in CKD. (a) Traditional view of the mechanisms that maintain secondary hyperparathyroidism in advanced chronic kidney disease. (b) Updated view of the mechanisms that initiate secondary hyperparathyroidism in chronic kidney disease, emphasizing the central role of FGF23. CaR, calcium sensing receptor; FGFR, fibroblast growth factor receptor; PTH, parathyroid hormone; VDR, vitamin D receptor. Kidney International 2010 78, 947-949DOI: (10.1038/ki.2010.281) Copyright © 2010 International Society of Nephrology Terms and Conditions