Dual role of DRD1 in the dynamic regulation of RNA‐directed DNA methylation. Dual role of DRD1 in the dynamic regulation of RNA‐directed DNA methylation.

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Dual role of DRD1 in the dynamic regulation of RNA‐directed DNA methylation. Dual role of DRD1 in the dynamic regulation of RNA‐directed DNA methylation. DRD1 is required for RNA‐directed de novo methylation of Cs in all sequence contexts for the target promoters tested here. DRD1 is also needed for the complete erasure of methylation after segregation of the source of the RNA signal, as indicated by enhanced retention of CG methylation in drd1 mutants. This is particularly clear for the target α′ promoter, which normally loses most methylation after withdrawing the silencing trigger. Methylation is indicated by filled circles, the target promoter by the red line and short RNAs by red dashed lines. Tatsuo Kanno et al. EMBO Rep. 2005;6:649-655 © as stated in the article, figure or figure legend