Cross-resistance to human cationic antimicrobial peptides and to polymyxins mediated by the plasmid-encoded MCR-1? J. Dobias, L. Poirel, P. Nordmann

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Cross-resistance to human cationic antimicrobial peptides and to polymyxins mediated by the plasmid-encoded MCR-1? J. Dobias, L. Poirel, P. Nordmann Clinical Microbiology and Infection Volume 23, Issue 9, Pages 676.e1-676.e5 (September 2017) DOI: 10.1016/j.cmi.2017.03.015 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Percentage of bacterial survival as a function of peptide concentration. (a) Data for wild-type and MCR-1 E. coli strains. (b), (c) Data for E. coli and K. pneumoniae strains, respectively, with chromosomal colistin resistance mechanism and wild-type strains. TC24 and TC31 are E. coli J53 transconjugants obtained from donor strains Af24 and Af31, respectively. Data represent the experimental means (plain symbols) with respective range of the calculated means (vertical bars) for the cationic antimicrobial peptides LL-37(■), HD5 (●) and HDB3 (▲). Clinical Microbiology and Infection 2017 23, 676.e1-676.e5DOI: (10.1016/j.cmi.2017.03.015) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions