Results w the CI

Results

Results 140mg seems to act faster but then 70mg catches up? Already benefit at 1 mo

Results – Safety 572 (90.4%) of pts who received at least 1 erenumab and 278 (87.1%) of pts who received at least 1 placebo got all 6 doses Frequency and severity of adverse events similar btw groups No difference in EKG, LFTs, Cr, VS, WBC 35 (5.6%) of 628 pts who got tested for anti-erenumab binding Abs were + (8% in 70mg, 3.2 in the 140mg)

Limitations Exclusion criteria include: “no therapeutic response to more than two migraine-preventive treatment categories” – are we excluding the refractory patients? However, could be included if prior preventive discontinued for partial or unsustained response No hemiplegic migraine – why? Stratified randomization according to region (North Am vs other) and according to other preventive medication? prevents imbalance btw treatment groups for known factors that influence prognosis or treatment responsiveness Harmless bcuz doesn’t cause greater imbalance than expected by chance, unless there is a small # pts Useful because reduces type I and II errors, improves trial efficiency Migraine Physical Function Impact Diary (MPFID): what is it?

Summary Erenumab subQ at monthly doses of 70mg or 140mg decreases migraine frequency, decreases use of abortive, and improves daily function Strength of the study: includes impact on every day activity function Similar safety than placebo, 3% withdrew from trial 2/2 adverse events Further studies are needed to assess long term safety and durability of the effect

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