Changes of calcitonin gene-related peptide in primary sensory neurons and their central branch after nerve root compression of the dog Shigeru Kobayashi,

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Changes of calcitonin gene-related peptide in primary sensory neurons and their central branch after nerve root compression of the dog Shigeru Kobayashi, MD, PhD, Shinichi Sasaki, PT, Seiichiro Shimada, PT, Makoto Kaneyasu, OT, Yasutaka Mizukami, OT, Ippei Kitade, PT, Mayumi Ogawa, PT, Hideo Kawahara, MD, Hisatoshi Baba, MD, PhD, Hidezo Yoshizawa, MD, PhD Archives of Physical Medicine and Rehabilitation Volume 86, Issue 3, Pages 527-533 (March 2005) DOI: 10.1016/j.apmr.2004.03.037 Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 1 Photomicrographs of CGRP-positive cells in the DRG of control group. Many small cells exhibiting positively for CGRP were observed in the DRG. Original magnification, ×20. Archives of Physical Medicine and Rehabilitation 2005 86, 527-533DOI: (10.1016/j.apmr.2004.03.037) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 2 Photomicrographs of CGRP-positive cells in the DRG after nerve root compression. After compression for 1 week, the number of CGRP-positive cells decreased markedly under compression at 60gf. Original magnification, ×20. Arrows indicate the CGRP-positive cells. Archives of Physical Medicine and Rehabilitation 2005 86, 527-533DOI: (10.1016/j.apmr.2004.03.037) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 3 Changes in CGRP-positive cells in the DRG after nerve root compression. NOTE. Values are mean ± standard error. *Significant difference (P<.001) between the control and the indicated condition. Archives of Physical Medicine and Rehabilitation 2005 86, 527-533DOI: (10.1016/j.apmr.2004.03.037) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 4 Changes in CGRP in the axon of nerve root were categorized into 3 groups: (A) grade A, (B) grade B, and (C) grade C. Original magnification, ×20. Arrows indicate the compression site. Archives of Physical Medicine and Rehabilitation 2005 86, 527-533DOI: (10.1016/j.apmr.2004.03.037) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 5 Changes in CGRP in the L7 dorsal horn were categorized into 2 groups. (A) grade 0 and (B) grade 1. Original magnification, ×8. Arrows indicate the compression side. Archives of Physical Medicine and Rehabilitation 2005 86, 527-533DOI: (10.1016/j.apmr.2004.03.037) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 6 Changes in CGRP in the primary sensory neurons and their central branch after nerve root compression. Archives of Physical Medicine and Rehabilitation 2005 86, 527-533DOI: (10.1016/j.apmr.2004.03.037) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions