Circadian biology: Clocks for the real world

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Circadian biology: Clocks for the real world Harriet McWatters, Jay C Dunlap, Andrew J Millar  Current Biology  Volume 9, Issue 17, Pages R633-R635 (September 1999) DOI: 10.1016/S0960-9822(99)80410-2

Figure 1 (a) Three-component model of the circadian system. (b) The frq–Frq–Wc feedback loop and its putative interactions with the Frq-less oscillator in the control of rhythmic conidiation in Neurospora. Current Biology 1999 9, R633-R635DOI: (10.1016/S0960-9822(99)80410-2)

Figure 2 (a) Daylengths are longer in summer than in winter, yet people wake up at the same time throughout the year, experiencing phase disturbances only when clocks are put forward or back, giving one twenty-five or twenty-three hour day. BST, British summer time; GMT, Greenwich mean time. (b) Entrainment of a biological clock causes the phase relationship between an observed rhythm and the Zeitgeber to vary, depending on the period of the Zeitgeber (T) and of the clock (τ). In contrast, an activity that is driven by the light or temperature step occurs at a fixed time relative to dawn (or the cold–warm transition of a temperature cycle, C–W), independently of T. The shaded box indicates darkness or cold temperature. Current Biology 1999 9, R633-R635DOI: (10.1016/S0960-9822(99)80410-2)