Andrew G. Muntean, Jay L. Hess Cancer Cell

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Presentation transcript:

MLL-AF9 Leukemia Stem Cells: Hardwired or Taking Cues from the Microenvironment? Andrew G. Muntean, Jay L. Hess Cancer Cell Volume 13, Issue 6, Pages 465-467 (June 2008) DOI: 10.1016/j.ccr.2008.05.012 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Microenvironment and Translocations Determine Lineage Outcome Several cells are capable of immortalization by MLL-AF9 (shaded in red) leading to acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), and acute biphenotypic leukemia (ABL) (with characteristics of both myeloid and lymphoid cells). Microenvironmental cues can cooperate with MLL fusion proteins to determine lineage outcome in leukemia of multipotent progenitors (CD34+) as well as progenitors that have partially differentiated (CD19+ and CD33+) (denoted by arrows). Cancer Cell 2008 13, 465-467DOI: (10.1016/j.ccr.2008.05.012) Copyright © 2008 Elsevier Inc. Terms and Conditions