Immune Protection Factors of Chemical Sunscreens Measured in the Local Contact Hypersensitivity Model in Humans  Peter Wolf, Christine Hoffmann, Franz Quehenberger, Stephan Grinschgl, Helmut Kerl  Journal of Investigative Dermatology  Volume 121, Issue 5, Pages 1080-1087 (November 2003) DOI: 10.1046/j.1523-1747.2003.12361.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Absorbance spectrum of the sunscreens. Sunscreens were applied to roughened quartz plates at 0.75 mg per cm2 and absorbance was measured spectroradiometrically at 1 nm intervals. The values given represent means from measurements performed at four different locations on each of four quartz plates. Journal of Investigative Dermatology 2003 121, 1080-1087DOI: (10.1046/j.1523-1747.2003.12361.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Dose–response curves for the different endpoint parameters (edema, clinical score, and diameter) in relation to applied MED and physical UV dose (J per cm2). Group A: sunscreen-untreated. Group B: treated with UVB sunscreen preparation no. 321. Group C: treated with UVA+B sunscreen no. 322. UV exposure doses applied in sunscreen treated groups B and C were multiples of the individual MED multiplied by the SPF of preparation no. 321 (5.2) and no. 322 (6.2), respectively. The exact S-shaped curves represent the logistic curves generated by the four-parameter model established for data analysis. The angular lines represent the linked mean values at the different UV doses applied. Note that there is a curve shift to the right for the curves of sunscreen-treated groups B and C compared with the sunscreen-untreated group A for all endpoints based on both MED and total physical UV dose applied, indicating that there was significant immunoprotection by both sunscreen preparations. Journal of Investigative Dermatology 2003 121, 1080-1087DOI: (10.1046/j.1523-1747.2003.12361.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions