Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion.

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Presentation transcript:

Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion of the cardiac donor population Satoru Osaki, MD, PhD, Matthew R. Locher, PhD, Entela B. Lushaj, MD, PhD, Shahab A. Akhter, MD, Takushi Kohmoto, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 3, Pages 1123-1130 (September 2014) DOI: 10.1016/j.jtcvs.2014.06.050 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Ex vivo perfusion system.9 The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1123-1130DOI: (10.1016/j.jtcvs.2014.06.050) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Contractile function for BD and DCD donors. BD, Brain dead; DCD, donation after cardiac death; LV-ESPVR, left ventricular end systolic pressure-volume relationship. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1123-1130DOI: (10.1016/j.jtcvs.2014.06.050) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Individual comparison and trend line of LV-ESPVR in BD and DCD hearts. A, Individual comparison of LV-ESPVR for BD hearts. B, Individual comparison of LV-ESPVR for DCD hearts. C, Trend line of LV-ESPVR for BD hearts. D, Trend line of LV-ESPVR for DCD hearts. BD, Brain dead; DCD, donation after cardiac death; LV-ESPVR, left ventricular end systolic pressure-volume relationship; WIT, warm ischemic time. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1123-1130DOI: (10.1016/j.jtcvs.2014.06.050) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Individual left ventricular end systolic pressure-volume relationship (LV-ESPVR) and left ventricular end diastolic pressure-volume relationship (LV-EDPVR) plots in BD and DCD hearts at 90 minutes of reperfusion. A, Individual LV-ESPVR plots for BD hearts. B, Individual LV-ESPVR plots for DCD hearts. C, Individual LV-EDPVR plots for BD hearts. D, Individual LV-EDPVR plots for DCD hearts. LV-ESP, Left ventricular end systolic pressure; BD, brain dead; DCD, donation after cardiac death; LV-EDP, left ventricular end diastolic pressure. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1123-1130DOI: (10.1016/j.jtcvs.2014.06.050) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions