Figure Neuroimaging and pathology

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Presentation transcript:

Figure Neuroimaging and pathology Neuroimaging and pathology (A) Pretreatment T1-weighted MRI shows curvilinear, punctate gadolinium contrast enhancement, predominantly in the pons. (B) Pretreatment T2-weighted MRI shows multiple T2 hyperintense lesions in the brainstem. (C) Posttreatment T1-weighted MRI shows resolution of previously enhancing areas of the brainstem. (D) Posttreatment T2-weighted MRI shows faint, patchy T2 hyperintensities in the areas of previous contrast enhancement in the pons. (E, F) Low- and high-power images of the H&E-stained slides (original magnification ×100 and ×200, respectively) of the left parietal brain biopsy showing with prominent small perivascular lymphocytes and more diffuse infiltration by macrophages. (G) Most of the lymphocytes label as CD3+ T cells (original magnification ×200). (H) Many of these T cells express CD8 (original magnification ×400). (I) There is a paucity of CD20+ staining B cells in the sample (original magnification ×200; the same region shown in G). (J) CD68 confirms the presence of numerous foamy macrophages (original magnification ×200). Veronica P. Cipriani et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e448 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology