Acute Kidney Injury: A Relevant Complication After Cardiac Surgery

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Presentation transcript:

Acute Kidney Injury: A Relevant Complication After Cardiac Surgery Giovanni Mariscalco, MD, PhD, Roberto Lorusso, MD, PhD, Carmelo Dominici, MD, Attilio Renzulli, MD, PhD, Andrea Sala, MD The Annals of Thoracic Surgery Volume 92, Issue 4, Pages 1539-1547 (October 2011) DOI: 10.1016/j.athoracsur.2011.04.123 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Pathogenesis and clinical phases of acute kidney injury [15]. (ATP = adenosine triphosphate; COPD = chronic obstructive pulmonary disease; CPB = cardiopulmonary bypass; IABP = intraaortic balloon pump; POSTOP = postoperative.) The Annals of Thoracic Surgery 2011 92, 1539-1547DOI: (10.1016/j.athoracsur.2011.04.123) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Continuous relationship between postoperative renal dysfunction and mortality risk: preoperative glomerular filtration rate (GFR) 30 mL · min−1 · 1.73m−2 (dotted line), 60 mL · min−1 · 1.73m−2 (dashed line), and 90 mL · min−1 · 1.73m−2 (solid line). (Reprinted by permission from Macmillan Publishers Ltd: Thakar CV, et al, Kidney Int 2005;67:1112–9 [74], copyright 2005.) The Annals of Thoracic Surgery 2011 92, 1539-1547DOI: (10.1016/j.athoracsur.2011.04.123) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Survival by duration of acute kidney injury (AKI). The proportion of patients surviving from the time of cardiac surgery is plotted by the categories for the duration of AKI: no AKI (gray line), AKI for 1 to 2 days, for 3 to 6 days, and for 7 days or more (black lines [p < 0.001 by log rank test]). (Reprinted with permission from Brown JR et al, Ann Thorac Surg 2010;90:1142–8 [11].) The Annals of Thoracic Surgery 2011 92, 1539-1547DOI: (10.1016/j.athoracsur.2011.04.123) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions