Ascl2 Reinforces Intestinal Stem Cell Identity

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Presentation transcript:

Ascl2 Reinforces Intestinal Stem Cell Identity Kelley S. Yan, Calvin J. Kuo Cell Stem Cell Volume 16, Issue 2, Pages 105-106 (February 2015) DOI: 10.1016/j.stem.2015.01.014 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Ascl2 Acts as a Bistable Switch in Response to Wnt/R-spondin In the Lgr5+ intestinal stem cell (ISC), Wnt/Rspo signals induce Ascl2, which undergoes positive auto-regulation and conversion from an Ascl2 “off” state to an Ascl2 “on” state, consistent with a bistable switch. Wnt/Rspo regulation of Ascl2 is also governed by hysteresis where previous Wnt/Rspo exposure enhances the ability of Wnt/Rspo to induce the Ascl2 “on” state, thereby stabilizing the stem cell identity of the Lgr5+ ISC. Ascl2 further cooperates with β-catenin/Tcf4 to transcriptionally activate stem cell loci that define Lgr5+ ISC identity. Cell Stem Cell 2015 16, 105-106DOI: (10.1016/j.stem.2015.01.014) Copyright © 2015 Elsevier Inc. Terms and Conditions