Volume 42, Issue 4, Pages 604-605 (April 2005) Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver  Thomas Pusl, Frank Rhode, Thomas Ott, Birgit Drabent, Klaus Willecke, Ulrich Beuers  Journal of Hepatology  Volume 42, Issue 4, Pages 604-605 (April 2005) DOI: 10.1016/j.jhep.2004.12.020 Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Effect of bile acids on bile flow in perfused livers of wild-type (WT) and Cx32-knockout mice (KO). Isolated livers were perfused in situ for 90min and bile flow measured gravimetrically in 15-min fractions. After 45min, the bile acid taurolithocholic acid (TLCA) alone or in combination with tauroursodeoxycholic acid (TUDCA) were infused for 45min at a continuous rate into the perfusion medium to reach a final concentration of 10μmol/L, respectively, in the portal vein. Bile flow measurements in the perfused livers were scaled by baseline bile flow (15–45min) in each experiment to minimize variability during comparisons. Means±SEM, n=3–4. Journal of Hepatology 2005 42, 604-605DOI: (10.1016/j.jhep.2004.12.020) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions