Figure 2 Immuno–neuro–endocrine interactions in the thymus Figure 2 | Immuno–neuro–endocrine interactions in the thymus. The thymus can be influenced by both peptide and nonpeptide hormones. The neuroendocrine control of the thymus includes sympathetic and parasympathetic innervation of the organ, with local release of neurotransmitters such as NE and ACh. Abbreviations: ACh, acetylcholine; ACTH, adrenocorticopropic hormone; AVP, arginine vasopressin; CRH, corticotropin-releasing hormone; DRG, dorsal root ganglion; E2, estradiol; Epi, epinephrine; GC, glucocorticoid; GH, growth hormone; GHRH, GH-releasing hormone; LH, luteinizing hormone; NE, norepinephrine; OT, oxytocin; PRL, prolactin; Prog, progesterone; TRH, thyrotropin-releasing hormone. Savino, W. et al. (2015) Hormonal control of T‑cell development in health and disease Nat. Rev. Endocrinol. doi:10.1038/nrendo.2015.168