Influence of Nerve Transsections and Combined Bladder Filling on Intravesical Electrostimulation-Induced Bladder Contraction in the Rat Filip De Bock,

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Presentation transcript:

Influence of Nerve Transsections and Combined Bladder Filling on Intravesical Electrostimulation-Induced Bladder Contraction in the Rat Filip De Bock, Stefan De Wachter, Jean Jacques Wyndaele European Urology Volume 56, Issue 3, Pages 527-533 (September 2009) DOI: 10.1016/j.eururo.2008.04.039 Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 1 The experimental setup. Catheter: 1. 22-gauge, IV catheter, 2. Y-piece, 3. Tuohy-Borst adapter, 4. Three-way valve, 5. Platinum-iridium wire. Levels of bilateral nerve transsection: (a) L6 dorsal root, (b) L6 ventral root, (c) pelvic nerve, (d) major pelvic ganglion. European Urology 2009 56, 527-533DOI: (10.1016/j.eururo.2008.04.039) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 2 Graphical representation of (a) the nerve transsection protocol and (b) the simultaneous filling and electrical stimulation protocol. European Urology 2009 56, 527-533DOI: (10.1016/j.eururo.2008.04.039) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 3 A typical example of the pressure development with (a) combined bladder filling and intravesical electrical stimulation (fill-IVES; 6mA), (b) bladder filling only, (c) IVES only (6mA). (I. Start fill, II. Stop fill, III. Start stimulation, IV. Stop stimulation). European Urology 2009 56, 527-533DOI: (10.1016/j.eururo.2008.04.039) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 4 Relative pressure rise with baseline taken as 100% pressure (± 95% confidential interval). * Significant different from baseline (p<0.0006). European Urology 2009 56, 527-533DOI: (10.1016/j.eururo.2008.04.039) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 5 (a) The time to reach a pressure increase (ΔP) equal to the time necessary to reach maximal ΔP with intravesical electrical stimulation (IVES). (b) Mean area under the curve. (c) Time necessary to reach maximal ΔP with IVES (6mA) for different bladder-filling grades (± standard deviation). *Significantly different with fill-IVES. European Urology 2009 56, 527-533DOI: (10.1016/j.eururo.2008.04.039) Copyright © 2008 European Association of Urology Terms and Conditions