Volume 139, Issue 1, Pages 120-129.e18 (July 2010) Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus  Alexander J. Thompson, Andrew J. Muir, Mark S. Sulkowski, Dongliang Ge, Jacques Fellay, Kevin V. Shianna, Thomas Urban, Nezam H. Afdhal, Ira M. Jacobson, Rafael Esteban, Fred Poordad, Eric J. Lawitz, Jonathan McCone, Mitchell L. Shiffman, Greg W. Galler, William M. Lee, Robert Reindollar, John W. King, Paul Y. Kwo, Reem H. Ghalib, Bradley Freilich, Lisa M. Nyberg, Stefan Zeuzem, Thierry Poynard, David M. Vock, Karen S. Pieper, Keyur Patel, Hans L. Tillmann, Stephanie Noviello, Kenneth Koury, Lisa D. Pedicone, Clifford A. Brass, Janice K. Albrecht, David B. Goldstein, John G. McHutchison  Gastroenterology  Volume 139, Issue 1, Pages 120-129.e18 (July 2010) DOI: 10.1053/j.gastro.2010.04.013 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Median reductions in viral load from baseline on the basis of IL-28B type. (A) Caucasian, (B) African American, and (C) Hispanic patients. Bars represent 25th and 75th percentiles. P < .001 for all pairwise comparisons of median viral load for CC vs CT or TT using the Wilcoxon 2-sample test (see Supplementary Table 1 and 2). Gastroenterology 2010 139, 120-129.e18DOI: (10.1053/j.gastro.2010.04.013) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Virologic responses on treatment on the basis of IL-28B type and ethnicity. (A) Caucasian, (B) African American, and (C) Hispanic patients. EOTR, end-of-treatment response. Statistical comparisons are presented in Table 2. Gastroenterology 2010 139, 120-129.e18DOI: (10.1053/j.gastro.2010.04.013) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Median reductions in viral load from baseline on the basis of IL-28B genotype in the adherent subset. (A) Caucasians, (B) African Americans, and (C) Hispanics. Bars represent 25th and 75th percentiles. Statistical comparisons are presented in Supplementary Tables 7 and 8. Gastroenterology 2010 139, 120-129.e18DOI: (10.1053/j.gastro.2010.04.013) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 2 Virologic responses on treatment on the basis of IL-28B SNP genotype and ethnicity in the adherent subset. (A) Caucasians, (B) African Americans, and (C) Hispanics. EOTR, end-of-treatment response. Statistical comparisons are presented in Supplementary Tables 7 and 8. Gastroenterology 2010 139, 120-129.e18DOI: (10.1053/j.gastro.2010.04.013) Copyright © 2010 AGA Institute Terms and Conditions