Innovative Liposomes as a Transfollicular Drug Delivery System: Penetration into Porcine Hair Follicles  Sascha Jung, Nina Otberg, Gisela Thiede, Heike Richter, Wolfram Sterry, Steffen Panzner, Jürgen Lademann  Journal of Investigative Dermatology  Volume 126, Issue 8, Pages 1728-1732 (August 2006) DOI: 10.1038/sj.jid.5700323 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Histological cross-section with hair follicle of a skin sample taken 3 days after application of liposome type 2. SC=stratum corneum; Bar=500μm; close up: Bar=100μm. Journal of Investigative Dermatology 2006 126, 1728-1732DOI: (10.1038/sj.jid.5700323) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Fluorescence image of a histological cross-section of a hair follicle, taken 7 days after application of liposome type 4. Bar=100μm. Journal of Investigative Dermatology 2006 126, 1728-1732DOI: (10.1038/sj.jid.5700323) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Arrangement of the test areas and their subdivisions. Pig ear with a scheme of two test areas (each 4 × 4cm) and their subdivisions (each 1 × 4cm). Biopsies were taken from a different subdivision at different time points (1hour, 3, 5, and 7 days after application). Journal of Investigative Dermatology 2006 126, 1728-1732DOI: (10.1038/sj.jid.5700323) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions