Risk of Gastrointestinal Bleeding in Patients Taking Non–Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis Corey S. Miller,

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Presentation transcript:

Risk of Gastrointestinal Bleeding in Patients Taking Non–Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis Corey S. Miller, Alastair Dorreen, Myriam Martel, Thao Huynh, Alan N. Barkun Clinical Gastroenterology and Hepatology Volume 15, Issue 11, Pages 1674-1683.e3 (November 2017) DOI: 10.1016/j.cgh.2017.04.031 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Flowchart of the literature search and study selection. Clinical Gastroenterology and Hepatology 2017 15, 1674-1683.e3DOI: (10.1016/j.cgh.2017.04.031) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Forest plot of major gastrointestinal bleeding, non–vitamin k antagonist oral anticoagulant vs conventional therapy. Clinical Gastroenterology and Hepatology 2017 15, 1674-1683.e3DOI: (10.1016/j.cgh.2017.04.031) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 Forest plot of major gastrointestinal bleeding by individual non–vitamin k antagonist oral anticoagulant. (A) Dabigatran vs conventional therapy. (B) Rivaroxaban vs conventional therapy. Clinical Gastroenterology and Hepatology 2017 15, 1674-1683.e3DOI: (10.1016/j.cgh.2017.04.031) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 Forest plot of major gastrointestinal bleeding by individual non–vitamin k antagonist oral anticoagulant. (A) Apixaban vs conventional therapy. (B) Edoxaban vs conventional therapy. Clinical Gastroenterology and Hepatology 2017 15, 1674-1683.e3DOI: (10.1016/j.cgh.2017.04.031) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Potential bias of included studies using the Cochrane Risk Bias Tool. Clinical Gastroenterology and Hepatology 2017 15, 1674-1683.e3DOI: (10.1016/j.cgh.2017.04.031) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 2 Forest plot of major gastrointestinal bleeding, novel oral anticoagulant vs conventional therapy, and hazard ratios. IV, instrumental variables. Clinical Gastroenterology and Hepatology 2017 15, 1674-1683.e3DOI: (10.1016/j.cgh.2017.04.031) Copyright © 2017 AGA Institute Terms and Conditions