Neuroplasticity: An Appreciation From Synapse to System

Slides:

Advertisements

Similar presentations

Physical Therapy for Central Vestibular Dysfunction Kathryn E. Brown, MS, PT, NCS, Susan L. Whitney, PhD, PT, NCS, ATC, Gregory F. Marchetti, PhD, PT,

Advertisements

Group Physiotherapy Provides Similar Outcomes for Participants After Joint Replacement Surgery as 1-to-1 Physiotherapy: A Sequential Cohort Study Corinne.

Kristina S. Beekhuizen, PhD, PT, Edelle C. Field-Fote, PhD, PT

Safety of Primed Repetitive Transcranial Magnetic Stimulation and Modified Constraint- Induced Movement Therapy in a Randomized Controlled Trial in Pediatric.

Yuehong Yue, MD, Weiqun Song, PhD, Su Huo, MD, Maobin Wang, MD

Effects of Robot-Aided Bilateral Force-Induced Isokinetic Arm Training Combined With Conventional Rehabilitation on Arm Motor Function in Patients With.

Feasibility and Test-Retest Reliability of an Electroencephalography-Based Brain Mapping System in Children With Cerebral Palsy: A Preliminary Investigation

Cost-Effectiveness of Screening for Deep Vein Thrombosis by Ultrasound at Admission to Stroke Rehabilitation Richard D. Wilson, MD, Patrick K. Murray,

Medical Rehabilitation After Natural Disasters: Why, When, and How?

The Business Case for Adult Disability Care Coordination

Brain Injury Coping Skills Group: A Preventative Intervention for Patients With Brain Injury and Their Caregivers Samantha L. Backhaus, PhD, Summer L.

Aerobic Exercise Training in Addition to Conventional Physiotherapy for Chronic Low Back Pain: A Randomized Controlled Trial Carol W. Chan, PT, MSc,

James A. Sliwa, DO, Allen Heinemann, PhD, Patrick Semik, BA

Patient-Reported Upper Extremity Outcome Measures Used in Breast Cancer Survivors: A Systematic Review Shana Harrington, PT, PhD, SCS, MTC, Lori A. Michener,

Short-Latency Stretch Reflexes Do Not Contribute to Premature Calf Muscle Activity During the Stance Phase of Gait in Spastic Patients Mark de Niet,

Joost van Kordelaar, MSc, Erwin van Wegen, PhD, Gert Kwakkel, PhD

Sze-Jia Hong, MSc, Esther Y. Goh, MSc, Salan Y. Chua, MSc, Shamay S

Recovery of Standing Balance and Health-Related Quality of Life After Mild or Moderately Severe Stroke S. Jayne Garland, PhD, Tanya D. Ivanova, PhD,

Assessment of Inter-Hemispheric Imbalance Using Imaging and Noninvasive Brain Stimulation in Patients With Chronic Stroke David A. Cunningham, MS, Andre.

Comparison of Robotics, Functional Electrical Stimulation, and Motor Learning Methods for Treatment of Persistent Upper Extremity Dysfunction After Stroke:

Accuracy of Self-Reported Physical Activity as an Indicator of Cardiovascular Fitness Depends on Education Level Paul Gerrard, MD Archives of Physical.

Stepping in Persons Poststroke: Comparison of Voluntary and Perturbation-Induced Responses Katherine M. Martinez, PT, MA, Marie-Laure Mille, PhD, Yunhui.

Relationship Between Hip Abductor Rate of Force Development and Mediolateral Stability in Older Adults Shuo-Hsiu J. Chang, PT, MS, Vicki S. Mercer, PT,

Focal Hand Dystonia: Individualized Intervention With Repeated Application of Repetitive Transcranial Magnetic Stimulation Teresa Jacobson Kimberley,

Anouk Lamontagne, PhD, PT, Francine Malouin, PhD, PT, Carol L

Internally and Externally Paced Finger Movements Differ in Reorganization After Acute Ischemic Stroke Torunn Askim, PhD, Bent Indredavik, PhD, MD, Asta.

Anna M. Barrett, MD, Gregory P. Crucian, PhD, David Q

Patricia S. Smith, PhD, Hubert R

Cognitive impairments in the locked-in syndrome: A case report

Changes in Disability Following Physical Therapy Intervention for Patients With Low Back Pain: Dependence on Symptom Duration Mary Beth Badke, PT, PhD,

Leonid Kalichman, PT, PhD, Elisha Vered, PT, MEd, Lior Volchek, MD

Integrated Physical Therapy Intervention for a Person With Pectus Excavatum and Bilateral Shoulder Pain: A Single-Case Study Paul K. Canavan, PhD, PT,

Kristina S. Beekhuizen, PhD, PT, Edelle C. Field-Fote, PhD, PT

Archives of Physical Medicine and Rehabilitation

Interlimb Coordination During the Stance Phase of Gait in Subjects With Stroke Andreia S.P. Sousa, PhD, Augusta Silva, PhD, Rubim Santos, PhD, Filipa.

Katy Pedlow, PhD, Sheila Lennon, PhD, Colin Wilson, D Clin Psych

Cortical Reorganization and Associated Functional Motor Recovery After Virtual Reality in Patients With Chronic Stroke: An Experimenter-Blind Preliminary.

Responses of the Less Affected Arm to Bilateral Upper Limb Task Training in Early Rehabilitation After Stroke: A Randomized Controlled Trial Jacqui.

Marco Dozza, MS, Lorenzo Chiari, PhD, Fay B. Horak, PhD, PT

Use of a Combination of Ankle Pressure and SENSERite System to Treat Older Adults With Impaired Ankle Proprioception: A Single-Blind Experimental Study

Interventions to Promote Long-Term Participation in Physical Activity After Stroke: A Systematic Review of the Literature Jacqui H. Morris, PhD, Stephen.

Psychometric Properties of the Neck Disability Index and Numeric Pain Rating Scale in Patients With Mechanical Neck Pain Joshua A. Cleland, PT, PhD,

Feasibility of 2 Different Water-Based Exercise Training Programs in Patients With Parkinson's Disease: A Pilot Study Carlos Ayán, PhD, José Cancela,

Laurent Mourot, PhD, Christian Cluzeau, PT, Jacques Regnard, MD, PhD

Cortical Reorganization of Hand Motor Function to Primary Sensory Cortex in Hemiparetic Patients With a Primary Motor Cortex Infarct Sung Ho Jang, MD,

Motor Recovery of the Ipsilesional Upper Limb in Subacute Stroke

Michael A. Dimyan, MD, Monica A

Mental Practice With Motor Imagery: Evidence for Motor Recovery and Cortical Reorganization After Stroke Andrew J. Butler, PhD, PT, Stephen J. Page,

Biomechanic Evaluation of Upper-Extremity Symmetry During Manual Wheelchair Propulsion Over Varied Terrain Wendy J. Hurd, PhD, Melissa M. Morrow, MS,

Quantifying Nonuse in Chronic Stroke Patients: A Study Into Paretic, Nonparetic, and Bimanual Upper-Limb Use in Daily Life Marian E. Michielsen, MSc,

Noninvasive Cortical Stimulation in Neurorehabilitation: A Review

ACRM 2012 Summer Archives Supplement: Request for Proposals

Leigh A. Hale, PhD, Jan Piggot, MHSc

Effect of Multiple Physiotherapy Sessions on Functional Outcomes in the Initial Postoperative Period After Primary Total Hip Replacement: A Randomized.

Impact of Tactile Dysfunction on Upper-Limb Motor Performance in Children With Unilateral Cerebral Palsy Megan L. Auld, PhD, Roslyn N. Boyd, PhD, G.

Evaluating the Responsiveness of 2 Versions of the Gross Motor Function Measure for Children With Cerebral Palsy Hui-Yi Wang, PhD, Yi Hsin Yang, PhD

Prevalence of Myofascial Trigger Points in the Hip in Patellofemoral Pain Sean Roach, PhD, DPT, ATC, Eric Sorenson, PhD, ATC, Barbara Headley, MS, PT,

Organization news Archives of Physical Medicine and Rehabilitation

Archives of Physical Medicine and Rehabilitation

Randomized Controlled Trial of Peer Mentoring for Individuals With Traumatic Brain Injury and Their Significant Others Robin A. Hanks, PhD, Lisa J. Rapport,

Patterns of Normal Human Brain Plasticity After Practice and Their Implications for Neurorehabilitation Clare Kelly, PhD, John J. Foxe, PhD, Hugh Garavan,

A Systematic Review of the Outcomes of Cardiovascular Exercise Programs for People With Down Syndrome Karen J. Dodd, PhD, Nora Shields, PhD Archives.

Effects of Treadmill Exercise on Transcranial Magnetic Stimulation−Induced Excitability to Quadriceps After Stroke Larry W. Forrester, PhD, Daniel F.

Journal-Based CME Evaluation and Application

Kenneth J. Ottenbacher, PhD, OTR, James E. Graham, PhD, DC

Clare E. Milner, PhD, Mary E. O'Bryan, BSEd

ACRM News Archives of Physical Medicine and Rehabilitation

Weight-Bearing Asymmetry in Relation to Measures of Impairment and Functional Mobility for People With Knee Osteoarthritis Cory L. Christiansen, PT,

Hand Function and Motor Cortical Output Poststroke: Are They Related?

Distinguishing Patient Satisfaction With Treatment Delivery From Treatment Effect: A Preliminary Investigation of Patient Satisfaction With Symptoms After.

Presentation transcript:

Neuroplasticity: An Appreciation From Synapse to System Bernadette T. Gillick, PhD, MS, PT, Lance Zirpel, PhD Archives of Physical Medicine and Rehabilitation Volume 93, Issue 10, Pages 1846-1855 (October 2012) DOI: 10.1016/j.apmr.2012.04.026 Copyright © 2012 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 1 Mechanisms of synaptic change between 2 neurons. Abbreviations: Ca2+, calcium ion; Glu, glutamate; Mg2+, magnesium ion; Na+, sodium ion. Archives of Physical Medicine and Rehabilitation 2012 93, 1846-1855DOI: (10.1016/j.apmr.2012.04.026) Copyright © 2012 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 2 TMS. (A) Individual receiving TMS testing. (B) Motor-evoked response as indicated by electromyogram. Archives of Physical Medicine and Rehabilitation 2012 93, 1846-1855DOI: (10.1016/j.apmr.2012.04.026) Copyright © 2012 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 3 Child in CIMT. Note active use of the child's right, affected upper extremity while the left, unaffected upper extremity is constrained by the cast. Archives of Physical Medicine and Rehabilitation 2012 93, 1846-1855DOI: (10.1016/j.apmr.2012.04.026) Copyright © 2012 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 4 Conceptual representation of MEPs and corticospinal tract integrity in 2 subjects. (A) Subject with porencephalic cyst. With the use of TMS, no noted contralateral resting or active hand MEP was elicited in the ipsilesional hemisphere. MEP was elicited bilaterally by contralesional hemisphere. Contralateral control to both upper extremities is represented by nonlesioned hemisphere (red line). (B) Subject with birth-related middle cerebral artery ischemic infarct. Contralateral hand resting MEP was elicited in each hemisphere. Intact crossed corticospinal tract integrity is represented by yellow and red lines, respectively. Archives of Physical Medicine and Rehabilitation 2012 93, 1846-1855DOI: (10.1016/j.apmr.2012.04.026) Copyright © 2012 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 5 Exaggerated IHI and intervention. (A) Conventional transverse depiction of normal brain with right hemisphere on left. Right and left primary motor areas (M1) are in gray. Arrows reflect balanced IHI. (B) Infarct (white square) in right M1 surrounded by peri-infarct zone (red border), which is dysfunctional but can become functional if disinhibited. Compensatory behaviors with the nonparetic (right) hand directed by contralesional (left) M1 result in overactivity of a portion of left M1 (dark gray circle), which increases the IHI from the left to the right (thick arrow) and decreases excitability in some surviving neurons of ipsilesional (right) M1 (whitish gray = diaschisis). (C) Intervention includes rTMS (energy bolt) to left M1 to disrupt excitability there combined with forced use of paretic hand and nonuse of nonparetic hand. (D) Idealized outcome of disinhibited right M1 and associated rebalancing of IHI allowing function to return to peri-infarct zone (white square) and adjacent gray matter but not to infarct itself. Archives of Physical Medicine and Rehabilitation 2012 93, 1846-1855DOI: (10.1016/j.apmr.2012.04.026) Copyright © 2012 American Congress of Rehabilitation Medicine Terms and Conditions