Volume 82, Issue 12, Pages (December 2012)

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Presentation transcript:

Volume 82, Issue 12, Pages 1313-1320 (December 2012) Sodium challenge does not support an acute gastrointestinal–renal natriuretic signaling axis in humans Richard A. Preston, David Afshartous, Leonard R. Forte, Rolando Rodco, Alberto B. Alonso, Dyal Garg, Leopoldo Raij Kidney International Volume 82, Issue 12, Pages 1313-1320 (December 2012) DOI: 10.1038/ki.2012.269 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Sodium excretion in response to an IV versus oral sodium load (Mean (s.e.m.)). IV, intravenous; cUnaV, cumulative urine sodium excretion; UnaV, urinary sodium excretion. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 2 Individual sodium excretion curves. (a) 30mmol Na diet. (b) 200mmol Na diet. IV, intravenous; cUnaV, cumulative sodium excretion rate. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 3 Aldosterone response to oral versus intravenous (IV) sodium. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 4 Serum prouroguanylin and proguanylin levels in response to acute intravenous (IV) versus oral sodium load. pro-GN, prohormone proguanylin; pro-UGN, propeptide prouroguanylin. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 5 Correlation of fall in prohormone proguanylin (pro-UGN) with Na excretion (high sodium period). cUnaV, cumulative sodium excretion rate; IV, intravenous; pro-UGN, propeptide prouroguanylin. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 6 Blood pressure (mmHg). DBP, diastolic blood pressure; IV, intravenous; SBP, systolic blood pressure. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 7 Creatinine clearance (ml/min). IV, intravenous. Kidney International 2012 82, 1313-1320DOI: (10.1038/ki.2012.269) Copyright © 2012 International Society of Nephrology Terms and Conditions