Supplementary Figure 1 a b IL1RA (pg/mL) IL1A (pg/mL) MCP-1 (pg/mL)

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Supplementary Figure 1 a b IL1RA (pg/mL) IL1A (pg/mL) MCP-1 (pg/mL) Spearman correlation = -0.13; p=0.341 Spearman correlation = -0.04; p=0.780 IL1RA (pg/mL) IL1A (pg/mL) 5 20 100 500 1 5 50 500 0 10 20 30 40 0 10 20 30 40 % Cytotoxicity % Cytotoxicity Spearman correlation = -0.04; p=0.759 Spearman correlation = -0.04; p=0.624 MCP-1 (pg/mL) 200 500 1000 2000 TNF (pg/mL) 2 5 10 20 50 0 10 20 30 40 0 10 20 30 40 % Cytotoxicity % Cytotoxicity b IL1RA(pg/mL) IL1A (pg/mL) 0 100 300 500 0 10 20 control primary met control primary met MCP-1 (pg/mL) TNF (pg/mL) * 0 10 20 30 * 0 500 1500 * control primary met control primary met Supplementary Figure 1