Maxim B. Freidin, Neesa Bhudia, Eric Lim, Andrew G

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Presentation transcript:

Impact of Collection and Storage of Lung Tumor Tissue on Whole Genome Expression Profiling Maxim B. Freidin, Neesa Bhudia, Eric Lim, Andrew G. Nicholson, William O. Cookson, Miriam F. Moffatt The Journal of Molecular Diagnostics Volume 14, Issue 2, Pages 140-148 (March 2012) DOI: 10.1016/j.jmoldx.2011.11.002 Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 Sample collection pipeline. The Journal of Molecular Diagnostics 2012 14, 140-148DOI: (10.1016/j.jmoldx.2011.11.002) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 Clusters of the most statistically significant (FDR adjusted P < 0.0001) differentially expressed genes. A: A heat map and hierarchical cluster analysis of 661 genes differentially expressed (P < 0.0001) at two surgical and three histopathology lab sample times. B: A heat map and hierarchical cluster of 3700 genes detectable in the FFPE samples and differentially expressed (P < 0.0001) compared with earlier time points. The Journal of Molecular Diagnostics 2012 14, 140-148DOI: (10.1016/j.jmoldx.2011.11.002) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions