Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response by Fotios P. Panitsas, Maria Theodoropoulou,

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Presentation transcript:

Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response by Fotios P. Panitsas, Maria Theodoropoulou, Alexandra Kouraklis, Marina Karakantza, Georgios L. Theodorou, Nicholas C. Zoumbos, Alice Maniatis, and Athanasia Mouzaki Blood Volume 103(7):2645-2647 April 1, 2004 ©2004 by American Society of Hematology

Cytokine gene expression profiles in adult chronic ITP patients. Cytokine gene expression profiles in adult chronic ITP patients. Expression (mean ± SEM) of the cytokines studied at the mRNA level in control subjects, patients in active disease phase (PLT count < 100 × 109/L [< 100 000/mm3]), and patients in hematologic remission by peripheral blood mononuclear cells ex vivo and after in vitro stimulation with PMA and ionomycin (P/I). Asterisks denote significance using unpaired 2-tail t test (*P < .05; **P < .01). Comparisons among subject groups (controls, patients with active disease, and patients in remission) were made under the same experimental conditions (ex vivo PBMCs or stimulated PBMCs) for each cytokine separately. Fotios P. Panitsas et al. Blood 2004;103:2645-2647 ©2004 by American Society of Hematology

Th1/Th2, type-1/type-2 cytokine expression ratios and relevance to platelet concentration in adult chronic ITP patients. Th1/Th2, type-1/type-2 cytokine expression ratios and relevance to platelet concentration in adult chronic ITP patients. (A) Th1 cytokines (IL-2, IFN-γ) over Th2 cytokines (IL-4, IL-5) expression ratios (mean ± SEM) in controls, patients, patients with active disease, and patients in remission. Asterisks show statistical significance (*P < .05; **P < .01; ***P < .005). Unpaired 2-tail t test was used for comparison among groups. (B) Type-1 cytokines (IL-2, IFN-γ) over type-2 cytokines (IL-4, IL-5, IL-10, IL-3, IL-13) expression ratios (mean ± SEM) in controls, patients, patients with active disease, and patients in remission. Asterisks show statistical significance (*P < .05; **P < .01; ***P < .005). Unpaired 2-tail t test was used for comparison among groups. (C) Th1/Th2 cytokine expression ratio versus peripheral blood platelet concentration linear regression line (solid) with 95% confidence intervals (dotted lines) in ITP patients. r2 = 0.2515; P = .0174. Fotios P. Panitsas et al. Blood 2004;103:2645-2647 ©2004 by American Society of Hematology