DXS (exp. level: 1632) DXR (exp. level: 737) MCT (exp. level: 402)

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DXS (exp. level: 1632) DXR (exp. level: 737) MCT (exp. level: 402) CMK (exp. level: 251) Chlorophylls m=0.025; r=0.11; P=0.456 Chlorophylls m=0.006; r=0.31; P=0.050 Chlorophylls m=5x10-5; r=0.01; P=0.929 Chlorophylls m=3x10-4; r=0.08; P=0.609 Carotenoids m=-0.061; r=0.29; P=0.055 Carotenoids m=0.006; r=0.37; P=0.016 Carotenoids m=5x10-4; r=0.11; P=0.491 Carotenoids m=2x10-5; r=0.004; P=0.979 Sterols m=-0.013; r=0.12; P=0.446 Sterols m=0.004; r=0.25; P=0.104 Sterols m=-5x10-4; r=0.12; P=0.456 Sterols m=0.001; r=0.32; P=0.032 MDS (exp. level: 604) HDS (exp. level: 1011) HDR (exp. level: 975) Chlorophylls m=0.011; r=0.37; P=0.019 Chlorophylls m=0.002; r=0.05; P=0.738 Chlorophylls m=-0.008; r=0.07; P=0.691 Carotenoids m=0.012; r=0.40; P=0.012 Carotenoids m=-0.002; r=0.03; P=0.834 Carotenoids m=-0.004; r=0.02; P=0.900 Sterols m=-8x10-5; r=0.0004; P=0.981 Sterols m=0.002; r=0.04 P=0.819 Sterols m=-0.011; r=0.16 P=0.384 Suplemental Figure S3. Gene-to-metabolite correlation analysis identifies genes with highest impact on chlorophyll and carotenoid accumulation. The expression levels of genes involved in the plastidial MEP pathway were modulated in transgenic Arabidopsis lines (fold-change vs. untransformed controls on x-axis). Major end products derived from this pathway (chlorophylls and carotenoids) were quantified (fold-change vs. untransformed controls on y-axis). Important parameters of the statistical analysis (m = slope; r = Pearson correlation coefficient; P = Student’s t-test P-value) and expression levels of each gene in rosette leaves (based on AtGenExpress microarray data resource (Schmid et al., 2005)) are provided above the graphs. Gray background is used to indicate positive gene-to-metabolite correlations. Acronyms: DXS, 1-deoxy-D-xylulose 5-phosphate synthase; DXR, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; MCT, 2C-methyl-D-erythritol 4-phosphate cytidyltransferase; CMK, 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase; MDS, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; HDS, 1-hydroxy-2-methyl-2-butenyl 4-phosphate synthase; HDR, 1-hydroxy-2-methyl-2-butenyl 4-phosphate reductase.