Treg's Alter Ego: An Accessory in Tumor Killing

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Treg's Alter Ego: An Accessory in Tumor Killing Ciriaco A. Piccirillo Immunity Volume 33, Issue 6, Pages 837-839 (December 2010) DOI: 10.1016/j.immuni.2010.12.005 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Functional Reprogramming of Foxp3+ Treg Cells in Tumors Whereas the thymus generates a subpopulation of Foxp3+ natural Treg cells, naive CD4+ T cells can also differentiate into Foxp3+ Treg cells after T cell activation in the presence of appropriate cytokines in the periphery. Sharma et al. (2010) show that the IDO-GCN2 pathway dominantly inhibits Treg cell reprogramming after vaccination to a cross-presented antigen, and such inhibition serves as a major mechanism to disable the priming of antitumor CD8+ T cells by vaccination. Immunity 2010 33, 837-839DOI: (10.1016/j.immuni.2010.12.005) Copyright © 2010 Elsevier Inc. Terms and Conditions