The Distinct Roles of JAM-A in Reovirus Pathogenesis

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The Distinct Roles of JAM-A in Reovirus Pathogenesis Carolyn B. Coyne Cell Host & Microbe Volume 5, Issue 1, Pages 3-5 (January 2009) DOI: 10.1016/j.chom.2008.12.009 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Models for the Role of JAM-A in Facilitating Reovirus Hematogenous Dissemination (A–C) The lining of the microvasculature is composed of a sheet of polarized endothelial cells that separate the bloodstream from the underlying tissue. JAM-A may mediate the hematogenous dissemination of reovirus by a number of mechanisms that may include (A) the facilitation of leukocyte transmigration across the endothelium, (B) the transcytosis and/or endocytosis of reovirus particles, and/or (C) the disassociation of JAM-JAM dimerization to allow for reovirus escape into the bloodstream. These possible mechanisms may exist in parallel or in some combination. Cell Host & Microbe 2009 5, 3-5DOI: (10.1016/j.chom.2008.12.009) Copyright © 2009 Elsevier Inc. Terms and Conditions