Takehiko Wada, Masaomi Nangaku Kidney International

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Novel roles of complement in renal diseases and their therapeutic consequences Takehiko Wada, Masaomi Nangaku Kidney International Volume 84, Issue 3, Pages 441-450 (September 2013) DOI: 10.1038/ki.2013.134 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Complement components and related molecules implicated in abnormal activation. The pathways of complement activation are depicted, with particular emphasis on the alternative pathway. The molecules highlighted in red are the complement components and the related molecules specifically discussed in this review. Ab, antibody; C3 con, C3 convertase; C3Nef, C3 nephritic factor; C3aR/C5aR, C3a receptor/C5a receptor; CFHRs, complement factor H–related proteins; MASPs, mannose-binding protein–associated serine proteases; MBL, mannose-binding lectin. Kidney International 2013 84, 441-450DOI: (10.1038/ki.2013.134) Copyright © 2013 International Society of Nephrology Terms and Conditions