In the Limelight: Ras, Ebola, Deubiquitinase, and Acetyl-CoA

Slides:

Advertisements

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Advertisements

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Structure-Based Engineering of Angucyclinone 6-Ketoreductases

Mastering the Chemical Language of Bacteria

Nucleosomes and Cisplatin

Volume 22, Issue 5, Pages v-vi (May 2015)

Tailor-Made Peptide Synthetases

Volume 14, Issue 4, Pages (April 2007)

Structural Basis for the Highly Selective Inhibition of MMP-13

Nucleosomes and Cisplatin

Deubiquitination of Lys63-Linkage by a CYLD UBP

Nature’s Strategy for Catalyzing Diels-Alder Reaction

RNA world: Catalysis abets binding, but not vice versa

Chemical Proteomics of Host-Pathogen Interaction

Volume 21, Issue 3, Pages (March 2014)

Matthieu Desroses, Mikael Altun Cell Chemical Biology

Volume 21, Issue 11, Pages (November 2014)

Adding Specificity to Artificial Transcription Activators

Finding the Missing Code of RNA Recognition by PUF Proteins

Deubiquitination of Lys63-Linkage by a CYLD UBP

Aptamers Meet Allostery

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Modularized Functions of the Fanconi Anemia Core Complex

DNA-Cation Interactions

Disruption of the interactions between the subunits of herpesvirus DNA polymerases as a novel antiviral strategy A. Loregian, G. Palù Clinical Microbiology.

Volume 14, Issue 5, Pages (May 2007)

Harnessing Host Defenses to HIV

A Trojan Horse for Human Immunodeficiency Virus

Volume 18, Issue 11, Pages (November 2011)

Riboswitches: Fold and Function

Aptamer Structures Chemistry & Biology

HAT Trick: p300, Small Molecule, Inhibitor

Steven G. Smith, Roberto Sanchez, Ming-Ming Zhou Chemistry & Biology

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

Volume 11, Issue 11, Pages (November 2004)

Volume 21, Issue 11, Pages (November 2014)

Volume 21, Issue 8, Pages v-vi (August 2014)

Filling a GAP—An Optimized Probe for ER Ca2+ Imaging In Vivo

Volume 12, Issue 11, Pages (November 2005)

Structural Basis for the Highly Selective Inhibition of MMP-13

Fueling Up Skeletal Muscle to Reduce Obesity: A TrkB Story

Nadja Heidrich, Jörg Vogel Molecular Cell

Breaking Down Order to Keep Cells Tidy

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases Ye Liu, Tengfei Zheng,

Structure-Based Engineering of Angucyclinone 6-Ketoreductases

Volume 15, Issue 8, Pages (August 2008)

Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets Andrew T. Krueger, Eric T. Kool Chemistry.

Nature’s Strategy for Catalyzing Diels-Alder Reaction

Keep the motor running Current Biology

L-DOPA Ropes in tRNAPhe

Volume 7, Issue 6, Pages R147-R151 (June 2000)

Ethan B. Butler, Yong Xiong, Jimin Wang, Scott A. Strobel

Structural Basis of Swinholide A Binding to Actin

Harnessing the Antioxidant Power with ARE-Inducing Compounds

Designing Chimeric LOV Photoswitches

Recent Advances in Microarray Technologies for Proteomics

Volume 21, Issue 9, Pages (September 2014)

Volume 21, Issue 7, Pages (July 2014)

Self-Assembling, Dynamic αPNAs

Allen R. Buskirk, David R. Liu Chemistry & Biology

Tools to Tackle Protein Acetylation

Volume 18, Issue 11, Pages (November 2011)

Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy Sarah R. Hengel, M. Ashley Spies, Maria Spies

Volume 4, Issue 3, Pages (March 2018)

Insights into Programmed Cell Death through Structural Biology

Structure-Based Engineering of Angucyclinone 6-Ketoreductases

Volume 16, Issue 6, Pages (June 2009)

Volume 21, Issue 9, Pages (September 2014)

Modularized Functions of the Fanconi Anemia Core Complex

Volume 22, Issue 4, Pages vii-viii (April 2015)

Presentation transcript:

In the Limelight: Ras, Ebola, Deubiquitinase, and Acetyl-CoA Chemistry & Biology Volume 21, Issue 3, Pages 307-308 (March 2014) DOI: 10.1016/j.chembiol.2014.03.003 Copyright © 2014 Terms and Conditions

Small-molecule modulators of SOS (light blue) are found to bind a hydrophobic cavity located close to the region of Ras (orange) involved in interactions with the SOS catalytic domain (gray). Image courtesy of S. Fesik. Chemistry & Biology 2014 21, 307-308DOI: (10.1016/j.chembiol.2014.03.003) Copyright © 2014 Terms and Conditions

Small-molecule chemical probe, ML323, binds and inhibits the USP1:UAF1 deubiquitinase complex, leading to insights about the connection between deubiquitination and two DNA damage response pathways; Fanconi anemia (FA) and DNA translesion synthesis (TLS). Image courtesy of Z. Zhuang and D. Maloney. Chemistry & Biology 2014 21, 307-308DOI: (10.1016/j.chembiol.2014.03.003) Copyright © 2014 Terms and Conditions