Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma Koei Ikeda, MD, PhD, Kenji Shiraishi,

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Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma Koei Ikeda, MD, PhD, Kenji Shiraishi, MD, PhD, Ayami Eguchi, MT, Hidekatsu Shibata, MD, PhD, Kentaro Yoshimoto, MD, PhD, Takeshi Mori, MD, PhD, Yoshifumi Baba, MD, PhD, Hideo Baba, MD, PhD, Makoto Suzuki, MD, PhD The Annals of Thoracic Surgery Volume 96, Issue 5, Pages 1790-1794 (November 2013) DOI: 10.1016/j.athoracsur.2013.06.035 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 The long interspersed nucleotide element 1 methylation levels in lung adenocarcinoma and matched normal lung specimens. The cancer tissues showed significantly lower levels of methylation than the matched normal lung (p < 0.001 by the paired t test). The Annals of Thoracic Surgery 2013 96, 1790-1794DOI: (10.1016/j.athoracsur.2013.06.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Kaplan-Meier curves for disease-free survival according to quartiles (Q1 to Q4) of LINE-1 methylation in lung adenocarcinoma. Q1: blue line, Q2: red line, Q3: green line, Q4: purple line. (B)(C)(D) Kaplan-Meier curves for disease-free survival; Q4 represents the “hypomethylated group” (green line) and Q1, Q2, and Q3 represent the “non-hypomethylation group” (blue line). The numbers inside the graphs represent the patients at risk in 0, 12, and 24 months after surgery. The Annals of Thoracic Surgery 2013 96, 1790-1794DOI: (10.1016/j.athoracsur.2013.06.035) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions