Scratch n’ Screen for Inhibitors of Cell Migration

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Presentation transcript:

Scratch n’ Screen for Inhibitors of Cell Migration Jon Soderholm, Rebecca Heald Chemistry & Biology Volume 12, Issue 3, Pages 263-265 (March 2005) DOI: 10.1016/j.chembiol.2005.03.001 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 High-Throughput Screening Using a Scratch Wound Healing Assay (A) Screening protocol in 384-well plate format. (B) Schematic of wound healing at a scratch boundary, where bordering cells initiate lamellar protrusion and migration toward the center of the wound. (C) Schematic of 16 wells before and after treatment with compounds during wound healing. Three wells, outlined in red, show defects in wound closure indicating the presence of inhibitory compounds. Chemistry & Biology 2005 12, 263-265DOI: (10.1016/j.chembiol.2005.03.001) Copyright © 2005 Elsevier Ltd Terms and Conditions