The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

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Presentation transcript:

The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit MJulie Thornton Journal of Investigative Dermatology Symposium Proceedings Volume 8, Issue 1, Pages 100-103 (June 2003) DOI: 10.1046/j.1523-1747.2003.12181.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Hypothetical model for the interdependence of estrogens and androgens in human skin. Aromatase activity can be upregulated by either testosterone or 5α-dihydrotestosterone binding to AR, thereby increasing the availability of 17β-estradiol. 5α-dihydrotestosterone can be 3β reduced by 3β-hydroxsteroid dehydrogenase (3β-HSD) to produce 5α-androstane-3β,17β-diol. Both 17β-estradiol and 5α-androstane-3β,17β-diol can bind to ERβ, which can downregulate AR expression. Blocking the production of 5α-dihydrotestosterone may inadvertently upregulate AR by (i) downregulating aromatase via AR inactivation, and (ii) inactivation of ERβ by limiting the availability of 5α-androstane-3β,17β-diol. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 100-103DOI: (10.1046/j.1523-1747.2003.12181.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Immunohistochemical localization of ERβ to human occipital scalp hair follicles (original magnification×250). Bound antibodies were visualized with diaminobenzidine and is seen as brown staining. Sections were counterstained with hematoxylin (blue nuclei). ERβ was widely expressed in the hair follicle bulb. Specific nuclear staining was seen in the mesenchymal dermal papilla and epithelial outer root sheath and hair matrix cells. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 100-103DOI: (10.1046/j.1523-1747.2003.12181.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Immunohistochemical localization of ERβ to human occipital scalp sebaceous glands (original magnification×128). Bound antibodies visualized with diaminobenzidine are seen as brown nuclear staining. Sections were counterstained with hematoxylin (blue nuclei). ERβ was widely expressed in the sebaceous gland, particularly in the partially differentiated sebocytes. Staining was not restricted to the nucleus, but was also present in the cytoplasm, particularly concentrated around the cell membrane. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 100-103DOI: (10.1046/j.1523-1747.2003.12181.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Immunohistochemical localization of ERβ to human occipital scalp skin (original magnification×100). Immunoreactive ERβ visualized with diaminobenzidine appears as brown nuclear staining, whereas nuclei counterstained with hematoxylin appear blue. Strong ERβ staining was restricted to the keratinocytes of the stratum basale and stratum spinosum, whereas the cells of the stratum granulosum were less immunoreactive. The stratum corneum was devoid of immunoreactivity for ERβ. In addition to the staining seen in the epidermis, the underlying fibroblasts of the papillary dermis also showed strong nuclear staining for ER. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 100-103DOI: (10.1046/j.1523-1747.2003.12181.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions