Motivation and drive in addiction

Slides:

Advertisements

Similar presentations

Brookhaven Science Associates U.S. Department of Energy Gene-Jack Wang, M.D. The Addiction-Obesity Connection Brookhaven Science Associates U.S. Department.

Advertisements

The Addicted Synapse Katie Malanson.

Drug Addiction.

Converging and Diverging Neurobiological Features of Feeding and Drug Self- Administration in Humans Dana M Small, PhD Alain Dagher, MD The John B Pierce.

What Neuroscience Has to Tell Us About Addiction as a Brain Disorder

MGlu5 receptor antagonists are neuroprotective against methamphetamine toxicity THDATGFAP Saline METH +MPEP +SIB-1893 Saline Methamphetamine (5 mg/kg x.

STRESS AND PLASTICITY.

Neurobiology of drug action and

The Neurobiology of Addiction

Drug Addiction Part II Karen Revere Kian Eftekhari Will Hiesinger.

Neurobiology of drug action and addiction Richard Palmiter Dept Biochemistry.

Neurobiology of Addiction

C2004 Alcohol Medical Scholars Program1 Craving Karen Drexler, M.D. Emory University School of Medicine.

This is Your Brain on Drugs Philip J. Pellegrino, Psy.D. 1.

From Intoxication to Addiction: Neurobiological Substrates for Hubris? Paul Fletcher Bernard Wolfe Health Neuroscience Fund The Intoxication.

Paula Riggs, MD Associate Professor Psychiatry University Colorado School of Medicine Supported by: NIDA 5U10DA13716, NIDA 5R01DA13176 Clinical Implications.

George F. Koob, Ph.D. Director

PSYC 2920 Lecture 8 Dependence, Addiction and the Self-Administration of Drugs Factors that Alter the Reinforcing Value of Drugs Other Deprivations and.

Neurocircuitry of Relapse. Circuitry Mediating Motivated Behavior VTA dopamine Basal Ganglia Anterior Cingulate Ventral Orbital Amygdala Hippocampus Opioids.

Methamphetamine, Behavior, and Brain Imaging Richard Rawson, Ph.D. UCLA Integrated Substance Abuse Programs CATES Methamphetamine Conference August 20,

Addiction: It’s a Brain Disease Beyond a Reasonable Doubt.

Nora D. Volkow, M.D. Director National Institute on Drug Abuse National Institutes of Health Nora D. Volkow, M.D. Director National Institute on Drug Abuse.

Neurocircuitry of Addiction: View from the Dark Side

1 Impaired Decision Making In Substance Use Disorders Claire Wilcox MD UNM Dept of Psychiatry Alcohol Medical Scholars Program © AMSP.

Neurological Disorders Lesson 5.1 What circuit do drugs affect in our brains?

The Neurobiology of Free Will In National Institute on Drug Abuse

Common Brain Mechanisms in ADDICTION Common Brain Mechanisms in ADDICTION Nora D. Volkow, M.D. Director National Institute on Drug Abuse Nora D. Volkow,

Increased Energy “It sustains and refreshes both body and brain in the same space of time more than double the amount of work could be undergone...”

The Neurobiology of Nicotine Dependence and Co-Morbid Psychiatric Disorders George F. Koob, Ph.D. Athina Markou, Ph.D. Department of Neuropharmacology.

Physiology and Behaviour of Withdrawal Syndrome Idrees M, Hussain A, Hyman A, Humphries R & Hughes E. Introduction: Chronic administration of certain drugs.

The Neural Basis of Addiction : A Pathology of Motivation and Choice Am J Psychiatry 162 : , August 2005.

알코올 의존, 질병의 경과와 항갈망제의 사용 Industry-sponsored lecture 알코올 의존, 질병의 경과와 항갈망제의 사용 Ki, Seon Wan M.D., Ph. D. Incheon St. Mary’s Hospital Incheon, Korea.

The Reward Pathway And Addiction

بنام خدا DR.KARIMI. DRUG ABUSE & MENTAL ILLNESS: Progress in Understanding COMORBIDITY DRUG ABUSE & MENTAL ILLNESS: Progress in Understanding COMORBIDITY.

Substance Use Disorders

Dopamine system: neuroanatomy

Mechanisms of Addiction

Opioids, Pain and Addiction

Reward - Drug Abuse Anatomy Physiology Pathophysiology

Defining Abnormality Medical approach Statistical approach

Common Brain Mechanisms of Chronic Pain and Addiction

Impaired Decision Making In Substance Use Disorders

Genetic Approaches to Functional Gastrointestinal Disorders

Dopamine pathways & antipsychotics

motivation, reward & addiction

Figure 2 Brain networks contributing to IBS symptoms

Regression slopes between percentage changes in Bmax′/Kd′ (dependent variable) in VS and absolute regional brain metabolic activity in OFC (BA 11), anterior.

Illegal Drug Use in the U.S.

Figure 3 Ascending pain pathways and the brain regions involved

Lithium: Mechanism of Action

The reward system in addiction

The Brain on Drugs: From Reward to Addiction

Cross-sectional integrated brain–gut model of IBS pathophysiology

Impulsivity, Compulsivity, and Top-Down Cognitive Control

Neurobiology of Addiction: The Gain in the Brain is in the Pain

Neurobiology of Depression

Ronald Keiflin, Patricia H. Janak Neuron

The role of the PFC in addiction

Internet Sex Addiction Treated With Naltrexone

by Myka L. Estes, and A. Kimberley McAllister

Circuitry of self-control and its role in reducing addiction

Substance Use Disorders

Changes in c-Fos expression evoked by the gambling test under the standard or double-reward condition. c-Fos expression was analyzed immunohistochemically.

Chapter 11 Drug Addiction

The Neurobiology of Addiction & the Pharmacology of Suboxone

by Myka L. Estes, and A. Kimberley McAllister

Social Decision-Making: Insights from Game Theory and Neuroscience

The Mysterious Motivational Functions of Mesolimbic Dopamine

Presentation transcript:

Motivation and drive in addiction

Behavioral activation Motivation Motivation Vigor Persistence Effort Behavioral activation DA Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

Increased motivation in addiction DA Dysregulated dopamine signaling Koob, G & Kandel, D et al. (2015). Pathophysiology of Addiction. In Tasman, A. . Psychiatry. West Sussex, England: Wiley Blackwell.

Increased motivation in addiction DA Drug-taking: primary motivational drive Dysregulated dopamine signaling Koob, G & Kandel, D et al. (2015). Pathophysiology of Addiction. In Tasman, A. . Psychiatry. West Sussex, England: Wiley Blackwell.

Motivation: neuroanatomy Dorsolateral PFC (DLPFC) PFC Nutt, D. & Nestor, L. (2013). Addiction. Oxford New York, NY: Oxford University Press.

Motivation: neuroanatomy Dorsolateral PFC (DLPFC) PFC Orbitofrontal cortex (OFC) Nutt, D. & Nestor, L. (2013). Addiction. Oxford New York, NY: Oxford University Press.

Motivation: neuroanatomy Anterior cingulate cortex (ACC) Nucleus Accumbens (NAc) Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

Motivation: neuroanatomy Anterior cingulate cortex (ACC) Amygdala Nucleus Accumbens (NAc) Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

Motivational deficits in drug addiction Acute withdrawal and protracted abstinence Motivational deficits Dysphoria Malaise Depression-like symptoms Koob, G & Kandel, D et al. (2015). Pathophysiology of Addiction. In Tasman, A. . Psychiatry. West Sussex, England: Wiley Blackwell.

The “antireward” system

The “antireward” system CRF Corticotropin-releasing factor Dysphoria Drug craving DYN Dynorphin NE Norepinephrine Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

The “antireward” system Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

The “antireward” system CRF NE DYN Stress Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

The “antireward” system Dysphoria Stress Craving Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.