Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery Christopher D.

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Presentation transcript:

Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery Christopher D. Owens, MD, Paul M. Ridker, MD, Michael Belkin, MD, Allen D. Hamdan, MD, Frank Pomposelli, MD, Frank Logerfo, MD, Mark A. Creager, MD, Michael S. Conte, MD Journal of Vascular Surgery Volume 45, Issue 1, Pages 2-9 (January 2007) DOI: 10.1016/j.jvs.2006.08.048 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Scatter plots indicate preoperative levels of inflammatory markers from 91 patients presenting for lower extremity bypass with critical and noncritical limb ischemia (CLI).A, High-sensitivity C-reactive protein (hsCRP) (mg/L). B, Fibrinogen (mg/dL). C, Serum amyloid A (SAA) (mg/dL). Data are presented as the median and interquartile range. Journal of Vascular Surgery 2007 45, 2-9DOI: (10.1016/j.jvs.2006.08.048) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 A, Scatter plot indicates the preoperative level of high-sensitivity C-reactive protein (hsCRP) in 91 patients, and compares those who experienced a postoperative composite end point (myocardial infarction, cerebrovascular accident, death, contralateral limb or graft-related event) with those who did not. Data are presented as the median and interquartile range. B, Freedom from reaching composite end point in subjects with elevated preoperative hsCRP (>5 mg/L) compared with those with levels within the reference range (≤5 mg/L) by Kaplan-Meier method (P = .018; log-rank test). C, Freedom from graft-related events (stenosis, revision, occlusion, or amputation of index leg) in subjects with elevated preoperative hsCRP (>5 mg/L) compared with those with levels within the reference range (≤5 mg/L) by Kaplan-Meier method (P = .094; log-rank test). Journal of Vascular Surgery 2007 45, 2-9DOI: (10.1016/j.jvs.2006.08.048) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions