Prognostic value of sustained elevated C-reactive protein levels in patients with acute aortic intramural hematoma Takeshi Kitai, MD, Shuichiro Kaji,

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Prognostic value of sustained elevated C-reactive protein levels in patients with acute aortic intramural hematoma Takeshi Kitai, MD, Shuichiro Kaji, MD, Kitae Kim, MD, Natsuhiko Ehara, MD, Tomoko Tani, MD, Makoto Kinoshita, MD, Yutaka Furukawa, MD The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 1, Pages 326-331 (January 2014) DOI: 10.1016/j.jtcvs.2012.11.030 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Kinetics of release of C-reactive protein (CRP) levels in patients with intramural hematoma. A, Time course change in mean CRP levels in all study patients with acute aortic intramural hematoma. Error bars indicate standard error of the mean. ∗P < .001 compared with CRP level on admission. B, Comparison of time course change in mean CRP levels and standard error of the mean in patients with intramural hematoma with and without adverse aorta-related events. Error bars indicate standard error of the mean. ∗P < .01 and †P < .001 compared with patients without aorta-related events. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 326-331DOI: (10.1016/j.jtcvs.2012.11.030) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Interval to adverse aorta-related event in patients with intramural hematoma. Comparison of aorta-related event-free survival curve in patients with (A) C-reactive protein (CRP) of 7.2 mg/dL or more at 2 weeks from onset and those with CRP less than 7.2 mg/dL and (B) among 4 subgroups: CRP less than 7.2 mg/dL without ulcer-like projection (ULP), CRP less than 7.2 mg/dL with ULP, CRP of 7.2 mg/dL or more without ULP, and CRP of 7.2 mg/dL or more with ULP. ∗P < .001 compared with CRP less than 7.2 mg/dL without ULP, CRP less than 7.2 mg/dL with ULP, and CRP of 7.2 mg/dL or more without ULP, respectively. Adverse aorta-related events included aortic rupture, aortic surgery, and significant aortic aneurysm without surgery. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 326-331DOI: (10.1016/j.jtcvs.2012.11.030) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions