Increased blood levels of NKG2D+CD4+ T cells in patients with alopecia areata Yong Hyun Jang, MD, PhD, Jin Kyeong Choi, PhD, Yun Hwan Jang, MD, Sun Young.

Slides:

Advertisements

Similar presentations

Treatment of generalized lichen nitidus with narrowband ultraviolet B Jae-Hong Park, MD, Yun-Lim Choi, MD, Won-Serk Kim, MD, Dong-Youn Lee, MD, Jun-Mo.

Advertisements

Molluscum contagiosum infection during the treatment of vitiligo with tacrolimus ointment Bong Kyun Ahn, MD, Byoung-Dae Kim, MD, Sang Ju Lee, MD, Seung.

Comparison of the Effects of Vapocoolant Spray and Topical Anesthetic Cream on Pain During Needle Electromyography in the Medial Gastrocnemius Young-Eun.

Tsung-Yu Tsai, MD, Yu-Chen Huang, MD

Comparison of the Effects of Vapocoolant Spray and Topical Anesthetic Cream on Pain During Needle Electromyography in the Medial Gastrocnemius Young-Eun.

Correlation between histopathologic findings of psoriasis determined using quantitative computer-aided analysis and elements of the Psoriasis Area and.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Systematic review and quality analysis of studies on the efficacy of topical diphenylcyclopropenone treatment for alopecia areata Yong Hyun Jang, MD,

A girl with a solitary red bulla

Yul W. Yang, MD, PhD, David J. DiCaudo, MD

Accuracy of biopsy sampling for subtyping basal cell carcinoma

Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Lucy Y. Liu, BA, Brittany.

Volume 4, Issue 3, Pages (April 2018)

Blaschkoid pityriasis rosea

Daniel S. Winchester, MD, Thomas L. Hocker, MD, Randall K. Roenigk, MD

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Baldness reversed by chemotherapy

House Dust Mite Increases pro-Th2 Cytokines IL-25 and IL-33 via the Activation of TLR1/6 Signaling Yong Hyun Jang, Jin Kyeong Choi, Meiling Jin, Young-Ae.

Expression of PD-L1 in mastocytosis

Array of cutaneous adverse effects associated with sorafenib

Treatment of pincer nail deformity using dental correction principles

Elana Putterman, BS, Leslie Castelo-Soccio, MD, PhD

Treatment of nevus depigmentosus using the 308-nm excimer laser: A retrospective study of 14 patients Jung Min Bae, MD, PhD, Han Mi Jung, MD, Hee Sun.

Primary thyroid marginal zone B-cell lymphoma in a patient with psoriatic arthritis treated with etanercept Hyunju Jin, MD, Hyun-Ho Cho, MD, Won-Jeong.

Permanent chemotherapy-induced alopecia: A review

Ming Yang Bi, AB, Jonathan L. Curry, MD, Angela M

Can the level of CD52 expression on Sézary cells be used to predict the response of Sézary syndrome to alemtuzumab? Iolanda Conde Fernandes, MD, Marta.

Elevated Galectin-10 Expression of IL-22-Producing T Cells in Patients with Atopic Dermatitis Seongmin Noh, Shan Jin, Chang Ook Park, Yun Sun Lee, Nara.

Whole-exome sequencing reveals differences between nail apparatus melanoma and acral melanoma Minho Lee, PhD, Jonghwan Yoon, BS, Yeun-Jun Chung, MD,

Blocking Potassium Channels (Kv1

Smoking and risk of psoriasis: A nationwide cohort study

A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis Lorinda Chung, MD, David Fiorentino,

Heterogeneous spectrum of acral melanoma: A clinicoprognostic study of 213 acral melanomas according to tumor site Hye Rim Moon, MD, Hyun Ji Kang, MD,

Chauncey C. Caldwell, MD, Sami K. Saikaly, MD, Robert P

Alopecia areata Journal of the American Academy of Dermatology

Telangiectatic cutaneous metastasis from lung adenocarcinoma

The applicability and prognostic value of the TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome.

Vitamin D deficiency in patients with chronic and acute urticaria: A systematic review and meta-analysis Tsung-Yu Tsai, MD, Yu-Chen Huang, MD Journal.

Natural killer cell response is a predictor of good outcome in MCPyV+ Merkel cell carcinoma: A case series of 23 patients Valerie Laniosz, MD, PhD, Oluwakemi.

A man with macroglossia and hemorrhagic bulla

Infectious rash after riding elephants

Loss of tumor cell CCR4 expression upon leukemic change in adult T-cell leukemia/lymphoma Kazunari Sugita, MD, Takatoshi Shimauchi, MD, Rieko Kabashima,

Molluscum contagiosum infection during the treatment of vitiligo with tacrolimus ointment Bong Kyun Ahn, MD, Byoung-Dae Kim, MD, Sang Ju Lee, MD, Seung.

Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis Min Young Park, MD,

CD4+CD25+FOXP3+ malignant T cells in Sézary syndrome are not necessarily functional regulatory T cells David A. Wada, MD, Mark R. Pittelkow, MD, Nneka.

Lip edema Journal of the American Academy of Dermatology

Lip and oral mucosal lesions in 100 renal transplant recipients

Treatment of alopecia areata with simvastatin/ezetimibe

Cortical Reorganization and Associated Functional Motor Recovery After Virtual Reality in Patients With Chronic Stroke: An Experimenter-Blind Preliminary.

Role of Cytotoxic T Cells in Chronic Alopecia Areata

Ustekinumab treatment is associated with decreased systemic and vascular inflammation in patients with moderate-to-severe psoriasis: Feasibility study.

Seasonal patterns in alopecia areata, totalis, and universalis

Medicaid acceptance among pediatric dermatologists

Clinical characteristics of chemotherapy-induced alopecia in childhood

A case of congenital erosive and vesicular dermatosis with limited involvement Ji Hyun Lee, MD, Sun Young Yoon, MD, Jeong Deuk Lee, MD, Sang Hyun Cho,

Increased risks of autoimmune rheumatic diseases in patients with psoriasis: A nationwide population-based study Hyun Jeong Ju, MD, Ki-Jo Kim, MD, PhD,

Alopecia areata is associated with impaired health-related quality of life: A survey of affected adults and children and their families Lucy Y. Liu,

Tsung-Yu Tsai, MD, Yu-Chen Huang, MD

Neural fibrolipoma Journal of the American Academy of Dermatology

Tofacitinib therapy for children with severe alopecia areata

Efficacy of topical diphenylcyclopropenone maintenance treatment for patients with alopecia areata: A retrospective study Sung Jay Choe, MD, Solam Lee,

Jose Fernández-Vozmediano, PhD, Jose Armario-Hita, MD

Klebsiella pneumoniae cellulitis in an immunocompetent man

Eyebrow transplantation: Alternative body sites as a donor source

A grayscale photograph with high dynamic range taken under a Wood's lamp for better recognition of vitiligo lesions Jung Min Bae, MD, PhD, Tae Young.

Classification of facial psoriasis based on the distributions of facial lesions Seung Man Woo, MD, Jung Won Choi, MD, Hyun Sun Yoon, MD, Seong Jin Jo,

Numerous hyperpigmented macules of the oral mucosa

Brittany G. Craiglow, MD, Brett A. King, MD, PhD

“Boot foot” with pseudomonas colonization

Investigation on the role of necroptosis in alopecia areata: A preliminary study Yong Hyun Jang, MD, PhD, Meiling Jin, MD, Sun Young Moon, MD, Dong Hyuk.

Presentation transcript:

Increased blood levels of NKG2D+CD4+ T cells in patients with alopecia areata Yong Hyun Jang, MD, PhD, Jin Kyeong Choi, PhD, Yun Hwan Jang, MD, Sun Young Moon, MD, Weon Ju Lee, MD, PhD, Seok-Jong Lee, MD, PhD, Young-Ae Choi, PhD, Sang-Hyun Kim, PhD, Do Won Kim, MD, PhD Journal of the American Academy of Dermatology Volume 76, Issue 1, Pages 151-153 (January 2017) DOI: 10.1016/j.jaad.2016.07.056 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Results of fluorescence-activated cell sorting (FACS) analysis of peripheral blood and natural killer group 2D (NKG2D)+CD4+ T, NKG2D+CD8+ T, and NKG2D+CD56+ NK cells in control and alopecia areata (AA) patient groups. Analysis of FACS data was carried out dividing into 4 times because of a large number of samples. The left bar graph indicates the average fold change of NKG2D+ cells from the 4 experiments (26 healthy controls and 43 patients with AA). NKG2D+ expressed on CD4+ T cells was significantly higher in AA patient groups compared to control groups, as with NKG2D+CD8+ T cells and NKG2D+CD56+ NK cells. The right dot plot shows the representative results taken from the third experiment (10 healthy controls and 10 patients with AA). Journal of the American Academy of Dermatology 2017 76, 151-153DOI: (10.1016/j.jaad.2016.07.056) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Double-immunofluorescence analysis with anti–natural killer group 2D (NKG2D; green) and anti-CD4 (red) antibodies. The merged image clearly shows infiltration of NKG2D+CD4+ T cells in the lesional hair follicles of patients with alopecia areata. The two white arrows indicate the location of hair follicle. Journal of the American Academy of Dermatology 2017 76, 151-153DOI: (10.1016/j.jaad.2016.07.056) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions