Volume 26, Issue 1, Pages (July 2017)

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Volume 26, Issue 1, Pages 142-156 (July 2017) Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses Rinke Stienstra, Romana T. Netea-Maier, Niels P. Riksen, Leo A.B. Joosten, Mihai G. Netea Cell Metabolism Volume 26, Issue 1, Pages 142-156 (July 2017) DOI: 10.1016/j.cmet.2017.06.001 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Metabolic Rewiring Observed in Myeloid Cells after Activation of TLR4 and TLR2 and during Induction of Trained Immunity After LPS stimulation, glycolysis is activated whereas oxidative phosphorylation is reduced, accommodating functional changes of the myeloid cells to mount an effective response. Activation of TLR2 promotes both glycolysis and oxidative phosphorylation, leading to differences in functional output of the myeloid cells. Epigenetic changes modulate gene transcription activation of trained immunity programs. Cell Metabolism 2017 26, 142-156DOI: (10.1016/j.cmet.2017.06.001) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Overview of Our Current Knowledge on Myeloid Cell Metabolism during Disease Cell Metabolism 2017 26, 142-156DOI: (10.1016/j.cmet.2017.06.001) Copyright © 2017 Elsevier Inc. Terms and Conditions