Deletion of mazG results in increased antibiotic killing.

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Date of download: 6/28/2016 Copyright © 2016 American Society of Anesthesiologists. All rights reserved. Increased interleukin (IL)-10 release induced.

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Deletion of mazG results in increased antibiotic killing. Deletion of mazG results in increased antibiotic killing. (A–D) Survival of stationary-phase cultures of Mtb strains treated with 10 mg/L Rif (A), 20 mg/L Cfx (B), 10 mg/L Str (C), or 10 mg/L INH (D). (E) After infection of THP-1 macrophages for 1 d, Mtb-infected macrophages were exposed to 1 mg/L Rif, 4 mg/L Str, or left untreated for 2 d. (F–H) Survival of stationary-phase cultures of Msm strains treated with 200 mg/L Rif (F), 30 mg/L Cfx (G), and 10 mg/L Str (H). com, the complemented mutant; wt, wild type. In all panels, survival was determined by monitoring colony-forming units (cfu) and was expressed relative to untreated control. Data shown are mean ± SE in triplicate. Significant values are *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Xiao-Yong Fan et al. PNAS 2018;115:9:2210-2215 ©2018 by National Academy of Sciences