Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis Prof Michael J Boivin, PhD, Daniel.

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Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis Prof Michael J Boivin, PhD, Daniel Okitundu, MD, Bumoko Makila-Mabe, MD, Marie-Therese Sombo, MD, Prof Dieudonne Mumba, PhD, Prof Alla Sikorskii, PhD, Prof Banea Mayambu, PhD, Prof Desire Tshala-Katumbay, PhD The Lancet Global Health Volume 5, Issue 9, Pages e936-e947 (September 2017) DOI: 10.1016/S2214-109X(17)30267-X Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 1 Change in urinary thiocyanate and (A) change in BOT-2 of motor proficiency standard total score and (B) change in KABC-II MPI score for children with konzo from baseline to 4-year follow-up Girls are depicted in blue along with the linear least square fit line and function, and boys are depicted in red. BOT-2=Bruininks-Oseretsky Test, second edition. KABC-II=Kaufman Assessment Battery for Children, second edition. MPI=Mental Processing Index. The Lancet Global Health 2017 5, e936-e947DOI: (10.1016/S2214-109X(17)30267-X) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 2 Change in BOT-2 total motor proficiency and change in urinary thiocyanate between baseline and 4-year follow up Change in urinary thiocyanate and change in BOT-2 of motor proficiency standard total score in (A) boys with konzo and (B) girls with konzo. BOT-2=Bruininks-Oseretsky Test, seconnd edition. DF=degrees of freedom. MSE=mean square error. The Lancet Global Health 2017 5, e936-e947DOI: (10.1016/S2214-109X(17)30267-X) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 3 Change in KABC-II MPI cognitive performance and change in urinary thiocyanate between baseline and 4-year followup Change in urinary thiocyanate and change in KABC-II MPI score for (A) boys with konzo and (B) girls with konzo. KABC-II=Kaufman Assessment Battery for Children, second edition. MPI=Mental Processing Index. DF=degrees of freedom. MSE=mean square error. The Lancet Global Health 2017 5, e936-e947DOI: (10.1016/S2214-109X(17)30267-X) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions