Identification and Validation of Biomarkers of IgVH Mutation Status in Chronic Lymphocytic Leukemia Using Microfluidics Quantitative Real-Time Polymerase.

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Presentation transcript:

Identification and Validation of Biomarkers of IgVH Mutation Status in Chronic Lymphocytic Leukemia Using Microfluidics Quantitative Real-Time Polymerase Chain Reaction Technology Lynne V. Abruzzo, Lynn L. Barron, Keith Anderson, Rachel J. Newman, William G. Wierda, Susan O'Brien, Alessandra Ferrajoli, Madan Luthra, Sameer Talwalkar, Rajyalakshmi Luthra, Dan Jones, Michael J. Keating, Kevin R. Coombes The Journal of Molecular Diagnostics Volume 9, Issue 4, Pages 546-555 (September 2007) DOI: 10.2353/jmoldx.2007.070001 Copyright © 2007 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 Unsupervised cluster analysis of the 29 CLL samples in the training set. Clustering was based on the mRNA expression of 86 candidate biomarkers on the custom MF-QRT-PCR card, using Pearson correlation to define distance and average linkage. The Journal of Molecular Diagnostics 2007 9, 546-555DOI: (10.2353/jmoldx.2007.070001) Copyright © 2007 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions