Vitamin C: C-ing a New Way to Fight Leukemia

Slides:

Advertisements

Similar presentations

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

Advertisements

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes Branden D. Tarlow, Carl Pelz, Willscott E. Naugler, Leslie.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Illuminating the Properties of Prostate Luminal Progenitors

The Tailless Root of Glioma: Cancer Stem Cells

Hematopoietic Stem Cells Burn Fat to Prevent Exhaustion

Martin Wahlestedt, David Bryder Cell Stem Cell

9-1-1: HSCs Respond to Emergency Calls

Volume 1, Issue 1, Pages (June 2007)

Cell Cycle Rules Pluripotency

The LUNGe to Model Alveolar Lung Diseases in a Dish

Guiding DNA Methylation

Adipocytes at the Core of Bone Function

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

Surveillance for Secure Differentiation

Christopher Hine, James R. Mitchell Cell Stem Cell

Andrew G. Muntean, Jay L. Hess Cancer Cell

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Christopher Hine, James R. Mitchell Cell Stem Cell

Natalia J. Martinez, Richard I. Gregory Cell Stem Cell

Regulating Cancer Stem Cells the miR Way

Wing Y. Chang, William L. Stanford Cell Stem Cell

Guillaume Richard-Carpentier, Guy Sauvageau Cell Stem Cell

Volume 11, Issue 3, Pages (September 2012)

A New Notch for Lung Stem Cells

Stem Cell Therapies in Clinical Trials: Progress and Challenges

Cancer Cell of Origin: Spotlight on Luminal Progenitors

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

HSPCs Get Their Motors Running for Asymmetric Fate Choice

MicroRNA Regulation of Stem Cell Fate

Imported Stem Cells Strike against Stroke

María García-Fernández, Simón Méndez-Ferrer Cell Stem Cell

Hakan Bagci, Amanda G. Fisher Cell Stem Cell

Early Embryos Reprogram DNA Methylation in Two Steps

Targeting β-catenin in CML: Leukemia Stem Cells Beware!

A New Therapeutic Target for Leukemia Comes to the Surface

Enhanc(er)ing Skin Stem Cells

Cycling toward Elimination of Leukemic Stem Cells

Mohammad Abdul-Ghani, Lynn A. Megeney Cell Stem Cell

Meddling with METTLs in Normal and Leukemia Stem Cells

Aspp1: A Guardian of Hematopoietic Stem Cell Integrity

Powering Reprogramming with Vitamin C

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Vitamin C: C-ing a New Way to Fight Leukemia

Sofia Gkountela, Amander T. Clark Cell Stem Cell

Madeline Niederkorn, Daniel T. Starczynowski Cell Stem Cell

Keeping the Epidermal Stem Cell Niche in Shape

HSC Fate Is Tethered to Mitochondria

Heterogeneity of Embryonic and Adult Stem Cells

Volume 22, Issue 4, Pages (April 2018)

Regulating Autologous Adult Stem Cells: The FDA Steps Up

ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity

The Tailless Root of Glioma: Cancer Stem Cells

Luisa Cimmino, Omar Abdel-Wahab, Ross L. Levine, Iannis Aifantis

Using Notches to Track Mammary Epithelial Cell Homeostasis

Stem Cells and Oxidants: Too Little of a Bad Thing

Mesp1 at the Heart of Mesoderm Lineage Specification

Volume 13, Issue 4, Pages (April 2008)

Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs

Ya-Huei Kuo, Ravi Bhatia Cell Stem Cell

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development

The Role of TET2 in Hematologic Neoplasms

Presentation transcript:

Vitamin C: C-ing a New Way to Fight Leukemia Katharina Schönberger, Nina Cabezas-Wallscheid Cell Stem Cell Volume 21, Issue 5, Pages 561-563 (November 2017) DOI: 10.1016/j.stem.2017.09.015 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Role of Vitamin C in Homeostatic HSC/MPPs and Aberrant LSC Function Tet proteins catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), a rate-limiting step toward DNA demethylation. In homeostasis, vitamin C regulates the balance between self-renewal, differentiation, and cell death of hematopoietic stem cells and multipotent progenitors (HSC/MPPs) by promoting Tet2 activity. In contrast, vitamin C depletion accelerates leukemogensis of Tet2-mutant leukemic stem cells (LSCs) and leads to increased aberrant self-renewal capacity. Cell Stem Cell 2017 21, 561-563DOI: (10.1016/j.stem.2017.09.015) Copyright © 2017 Elsevier Inc. Terms and Conditions