TFE3 regulates glucose homeostasis

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TFE3 regulates glucose homeostasis TFE3 regulates glucose homeostasis AGlucose levels in fed and after 24 h fasting in 2‐month‐old WT and Tfe3 KO mice (n = 12 per group). Data are presented as mean ± SEM. Student's two‐tailed t‐test: ***P < 0.001.B, CPlasma insulin (B) (n = 5 WT and n = 3 Tfe3 KO) and glucagon (C) (n = 12 per group) levels in WT and Tfe3 KO mice. Data are presented as mean ± SEM. Student's two‐tailed t‐test: **P = 0.0090; *P = 0.0404.D–FInsulin and glucose tolerance tests in WT and Tfe3 KO mice fed a chow diet. Glucose levels (D) at the indicated time points after insulin challenge (n = 3 per group). Glucose (E) (n = 20 per group) and serum insulin (F) (n = 5 per group) levels at the indicated time points after glucose challenge. Data are presented as mean ± SEM. ANOVA test followed by post hoc Bonferroni test: GTT ***P = 0.0003 15 min; *P = 0.0241 30 min; ***P = 0.0007 60 min; insulin during GTT ***P = 0.0005; *P = 0.0145.GPyruvate tolerance test in WT (black line; n = 5) and Tfe3 KO mice (red line; n = 4) fed a chow diet. Data are presented as mean ± SEM. ANOVA test followed by post hoc Bonferroni test: **P = 0.0053.HExpression analysis of genes involved in gluconeogenesis in the liver (n = 5 per group). Data are presented as mean ± SEM. Student's two‐tailed t‐test: **P = 0.0098; *P = 0.0216.I–KBlood glucose (I) (n = 4 per group), muscle glycogen content (J) (scale bars 50 μm) and blood lactate levels (K) (n = 6 Ctrl and Ex; n = 3 Ex+Rec) from mice with the indicated genotypes subjected to an exercise (Ex) and exercise plus 2‐h recovery protocol (Ex+Rec). Data are presented as mean ± SEM. Student's two‐tailed t‐test: blood glucose *P = 0.049; blood lactate *P = 0.027.LExpression analysis of Gsk3 in muscle of WT and Tfe3 KO mice fed a chow diet (n = 4 per group). Data are presented as mean ± SEM. Student's two‐tailed t‐test: *P = 0.0149. Nunzia Pastore et al. EMBO Mol Med. 2017;emmm.201607204 © as stated in the article, figure or figure legend