Biomarkers in Nephrology: Core Curriculum 2013

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Presentation transcript:

Biomarkers in Nephrology: Core Curriculum 2013 Gearoid M. McMahon, MB, BCh, Sushrut S. Waikar, MD, MPH American Journal of Kidney Diseases Volume 62, Issue 1, Pages 165-178 (July 2013) DOI: 10.1053/j.ajkd.2012.12.022 Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Anatomical localization of biomarkers along the nephron. Abbreviations: ADMA, asymmetric dimethyl arginine; CTGF, connective tissue growth factor; GGT, γ-glutamyl transpeptidase; GST, glutathione-S-transferase; IL-18, interleukin 18; KIM-1, kidney injury molecule 1; LDH, lactate dehydrogenase; L-FABP, liver-type fatty acid binding protein; NAG, N-acetyl glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin. American Journal of Kidney Diseases 2013 62, 165-178DOI: (10.1053/j.ajkd.2012.12.022) Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Pattern of change in biomarkers over time in patients with acute kidney injury following cardiac surgery. Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin. Conversion factor for units: serum creatinine in mg/dL to μmol/L, ×88.4. Data from Parikh CR, et al. Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol. 2011;22:1737-1747. American Journal of Kidney Diseases 2013 62, 165-178DOI: (10.1053/j.ajkd.2012.12.022) Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions