Obesity impairs apoptotic cell clearance in asthma

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Presentation transcript:

Obesity impairs apoptotic cell clearance in asthma Ruby Fernandez-Boyanapalli, PhD, Elena Goleva, PhD, Christena Kolakowski, MS, Elysia Min, MS, Brian Day, PhD, Donald Y.M. Leung, MD, PhD, David W.H. Riches, PhD, Donna L. Bratton, MD, E. Rand Sutherland, MD, MPH  Journal of Allergy and Clinical Immunology  Volume 131, Issue 4, Pages 1041-1047.e3 (April 2013) DOI: 10.1016/j.jaci.2012.09.028 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 4HNE concentrations in the plasma of nonobese (n = 10) and obese (n = 10) asthmatic patients. Journal of Allergy and Clinical Immunology 2013 131, 1041-1047.e3DOI: (10.1016/j.jaci.2012.09.028) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Efferocytosis by sputum macrophages and blood monocytes. A, Sputum was induced and processed as reported in the Methods section, and efferocytosis was assessed from cytospin preparations by using light microscopy. A representative image is shown. B, Efferocytosis of 5-μm carboxylated beads by monocytes was assessed by using light microscopy. A representative image is shown. Black arrows indicate beads that have been ingested by monocytes compared with beads bound to the surface, as represented by the red arrow. Journal of Allergy and Clinical Immunology 2013 131, 1041-1047.e3DOI: (10.1016/j.jaci.2012.09.028) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions