Radiographically determined noninvasive adenocarcinoma of the lung: Survival outcomes of Japan Clinical Oncology Group 0201 Hisao Asamura, MD, Tomoyuki.

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Presentation transcript:

Radiographically determined noninvasive adenocarcinoma of the lung: Survival outcomes of Japan Clinical Oncology Group 0201 Hisao Asamura, MD, Tomoyuki Hishida, MD, Kenji Suzuki, MD, Teruaki Koike, MD, Kenichi Nakamura, MD, Masahiko Kusumoto, MD, Kanji Nagai, MD, Hirohito Tada, MD, Tetsuya Mitsudomi, MD, Masahiro Tsuboi, MD, Taro Shibata, MSc, Haruhiko Fukuda, MD The Journal of Thoracic and Cardiovascular Surgery Volume 146, Issue 1, Pages 24-30 (July 2013) DOI: 10.1016/j.jtcvs.2012.12.047 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Calculation of the C/T ratio to define radiologic noninvasive lung cancer on TSCT. The maximum diameter of consolidation (C) is divided by the maximum tumor diameter (T) to give the C/T ratio. GGO, Ground-glass opacity; C/T, consolidation/tumor; TSCT, thin-section computed tomography. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 24-30DOI: (10.1016/j.jtcvs.2012.12.047) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Overall (A) and relapse-free (B) survival curves for the entire group (cT1a-b, ≤3.0 cm, n = 545). OS, Overall survival; RFS, relapse-free survival. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 24-30DOI: (10.1016/j.jtcvs.2012.12.047) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Overall (A) and relapse-free (B) survival curves for radiologically noninvasive (n = 121) and invasive (n = 424) adenocarcinomas based on a C/T ratio of 0.50 or less in cT1a-b (≤3.0 cm) for noninvasiveness on TSCT. The differences in overall and relapse-free survival are statistically significant (P < .001 and < .001, respectively). OS, Overall survival; RFS, relapse-free survival; C/T, consolidation/tumor; TSCT, thin-section computed tomography. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 24-30DOI: (10.1016/j.jtcvs.2012.12.047) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Overall (A) and relapse-free (B) survival curves for the cT1a (≤2.0 cm) group (n = 289). OS, Overall survival; RFS, relapse-free survival. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 24-30DOI: (10.1016/j.jtcvs.2012.12.047) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Overall (A) and relapse-free (B) survival curves for radiologically noninvasive (n = 35) and invasive (n = 254) adenocarcinomas based on a C/T ratio of 0.25 or less in cT1a (≤2.0 cm) for noninvasiveness on TSCT. The differences in overall and relapse-free survival are not statistically significant (P = .259 and .106, respectively). OS, Overall survival; RFS, relapse-free survival; C/T, consolidation/tumor; TSCT, thin-section computed tomography. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 24-30DOI: (10.1016/j.jtcvs.2012.12.047) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 6 Overall (A) and relapse-free (B) survival curves for radiologically noninvasive (n = 54) and invasive (n = 200) adenocarcinomas based on a C/T ratio ≤0.5 in cT1b (>2.0-3.0 cm) for noninvasiveness on TSCT. The differences in overall and relapse-free survival are statistically significant (P = .003 and .003, respectively). OS, Overall survival; RFS, relapse-free survival; C/T, consolidation/tumor; TSCT, thin-section computed tomography. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 24-30DOI: (10.1016/j.jtcvs.2012.12.047) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions